类固醇激素与组织驻留干细胞的生理调节：果蝇卵巢的启示。

IF 2.3 Q4 CELL & TISSUE ENGINEERING

Current Stem Cell Reports Pub Date : 2017-03-01 Epub Date: 2017-02-01 DOI:10.1007/s40778-017-0070-z

Elizabeth T Ables, Daniela Drummond-Barbosa

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引用次数: 0

摘要

综述的目的：干细胞对局部旁分泌信号做出反应；然而，最近系统激素也成为干细胞的关键调节因子。本综述以果蝇生殖干细胞为讨论中心，探讨类固醇激素在干细胞中的作用：最近的发现：干细胞直接或间接地感知类固醇激素并对其做出反应，类固醇激素通过与核激素受体的相互作用调节不同的靶基因。激素调控网络可能整合了多种系统信号的作用，以调整干细胞系的活性，应对生理状态的变化。阐明干细胞中激素信号传导的分子机制，对我们了解干细胞生物学的基本原理、为癌症或再生医学提供新的治疗干预措施至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary.

查看原文本刊更多论文

Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary.

Purpose of review: Stem cells respond to local paracrine signals; more recently, however, systemic hormones have also emerged as key regulators of stem cells. This review explores the role of steroid hormones in stem cells, using the Drosophila germline stem cell as a centerpiece for discussion.

Recent findings: Stem cells sense and respond directly and indirectly to steroid hormones, which regulate diverse sets of target genes via interactions with nuclear hormone receptors. Hormone-regulated networks likely integrate the actions of multiple systemic signals to adjust the activity of stem cell lineages in response to changes in physiological status.

Summary: Hormones are inextricably linked to animal physiology, and can control stem cells and their local niches. Elucidating the molecular mechanisms of hormone signaling in stem cells is essential for our understanding of the fundamental underpinnings of stem cell biology, and for informing new therapeutic interventions against cancers or for regenerative medicine.

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.