抗体信号传导:最新进展。

IF 26.9 1区医学 Q1 IMMUNOLOGY

Annual review of immunology Pub Date : 2017-04-26 DOI:10.1146/annurev-immunol-051116-052433

Stylianos Bournazos, Taia T Wang, Rony Dahan, Jad Maamary, Jeffrey V Ravetch

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引用次数: 156

摘要

IgG抗体通过Fab结构域将抗原特异性偶联到Fc-Fc受体相互作用的信号转导，从而介导多种免疫功能。事实上，通过I型和II型Fc受体平衡的IgG信号是控制促炎、抗炎和免疫调节过程所必需的。在这篇综述中，我们讨论了控制IgG-Fc受体相互作用的机制，强调了Fc受体介导的效应功能的多样性，这些功能调节免疫和炎症，以及决定对感染和自身免疫的易感性以及对基于抗体的治疗和疫苗的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Signaling by Antibodies: Recent Progress.

IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.

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来源期刊

Annual review of immunology 医学-免疫学

CiteScore

57.20

自引率

0.70%

发文量

期刊介绍： The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.