{"title":"暴露于龙葵后的角膜毒性。","authors":"Lauge Hjorth Mikkelsen, Hassan Hamoudi, Cigdem Altuntas Gül, Steffen Heegaard","doi":"10.2174/1874364101711010001","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To present a case of corneal toxicity following exposure to milky plant latex from <i>Asclepias tuberosa.</i></p><p><strong>Methods: </strong>A 70-year-old female presented with blurred vision and pain in her left eye after handling an <i>Ascepias tuberosa</i>. Clinical examination revealed a corneal stromal oedema with small epithelial defects. The corneal endothelium was intact and folds in Descemets membrane were observed. The oedema was treated with chloramphenicol, dexamethasone and scopolamine.</p><p><strong>Results: </strong>The corneal oedema had appeared after corneal exposure to the plant, <i>Asclepias tuberosa</i>, whose latex contains cardenolides that inhibit the Na<sup>+</sup>/ K<sup>+</sup>-ATPase in the corneal endothelium. The oedema resolved after 96 hours. After nine months the best corrected visual acuity was 20/20.</p><p><strong>Conclusion: </strong>Corneal toxicity has previously been reported for plants of the <i>Asclepias</i> family. This is a rare case describing severe corneal toxicity caused by exposure to latex from <i>Asclepias tuberosa</i>. Handling of plants of the <i>Asclepias</i> family should be kept as a differential diagnosis in cases of acute corneal toxicity.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"11 ","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/5b/TOOPHTJ-11-1.PMC5362972.pdf","citationCount":"9","resultStr":"{\"title\":\"Corneal Toxicity Following Exposure to <i>Asclepias Tuberosa</i>.\",\"authors\":\"Lauge Hjorth Mikkelsen, Hassan Hamoudi, Cigdem Altuntas Gül, Steffen Heegaard\",\"doi\":\"10.2174/1874364101711010001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To present a case of corneal toxicity following exposure to milky plant latex from <i>Asclepias tuberosa.</i></p><p><strong>Methods: </strong>A 70-year-old female presented with blurred vision and pain in her left eye after handling an <i>Ascepias tuberosa</i>. Clinical examination revealed a corneal stromal oedema with small epithelial defects. The corneal endothelium was intact and folds in Descemets membrane were observed. The oedema was treated with chloramphenicol, dexamethasone and scopolamine.</p><p><strong>Results: </strong>The corneal oedema had appeared after corneal exposure to the plant, <i>Asclepias tuberosa</i>, whose latex contains cardenolides that inhibit the Na<sup>+</sup>/ K<sup>+</sup>-ATPase in the corneal endothelium. The oedema resolved after 96 hours. After nine months the best corrected visual acuity was 20/20.</p><p><strong>Conclusion: </strong>Corneal toxicity has previously been reported for plants of the <i>Asclepias</i> family. This is a rare case describing severe corneal toxicity caused by exposure to latex from <i>Asclepias tuberosa</i>. Handling of plants of the <i>Asclepias</i> family should be kept as a differential diagnosis in cases of acute corneal toxicity.</p>\",\"PeriodicalId\":512318,\"journal\":{\"name\":\"The Open Ophthalmology Journal\",\"volume\":\"11 \",\"pages\":\"1-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/5b/TOOPHTJ-11-1.PMC5362972.pdf\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Ophthalmology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874364101711010001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Ophthalmology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874364101711010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Corneal Toxicity Following Exposure to Asclepias Tuberosa.
Purpose: To present a case of corneal toxicity following exposure to milky plant latex from Asclepias tuberosa.
Methods: A 70-year-old female presented with blurred vision and pain in her left eye after handling an Ascepias tuberosa. Clinical examination revealed a corneal stromal oedema with small epithelial defects. The corneal endothelium was intact and folds in Descemets membrane were observed. The oedema was treated with chloramphenicol, dexamethasone and scopolamine.
Results: The corneal oedema had appeared after corneal exposure to the plant, Asclepias tuberosa, whose latex contains cardenolides that inhibit the Na+/ K+-ATPase in the corneal endothelium. The oedema resolved after 96 hours. After nine months the best corrected visual acuity was 20/20.
Conclusion: Corneal toxicity has previously been reported for plants of the Asclepias family. This is a rare case describing severe corneal toxicity caused by exposure to latex from Asclepias tuberosa. Handling of plants of the Asclepias family should be kept as a differential diagnosis in cases of acute corneal toxicity.
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