{"title":"暴露于龙葵后的角膜毒性。","authors":"Lauge Hjorth Mikkelsen, Hassan Hamoudi, Cigdem Altuntas Gül, Steffen Heegaard","doi":"10.2174/1874364101711010001","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To present a case of corneal toxicity following exposure to milky plant latex from <i>Asclepias tuberosa.</i></p><p><strong>Methods: </strong>A 70-year-old female presented with blurred vision and pain in her left eye after handling an <i>Ascepias tuberosa</i>. Clinical examination revealed a corneal stromal oedema with small epithelial defects. The corneal endothelium was intact and folds in Descemets membrane were observed. The oedema was treated with chloramphenicol, dexamethasone and scopolamine.</p><p><strong>Results: </strong>The corneal oedema had appeared after corneal exposure to the plant, <i>Asclepias tuberosa</i>, whose latex contains cardenolides that inhibit the Na<sup>+</sup>/ K<sup>+</sup>-ATPase in the corneal endothelium. The oedema resolved after 96 hours. After nine months the best corrected visual acuity was 20/20.</p><p><strong>Conclusion: </strong>Corneal toxicity has previously been reported for plants of the <i>Asclepias</i> family. This is a rare case describing severe corneal toxicity caused by exposure to latex from <i>Asclepias tuberosa</i>. Handling of plants of the <i>Asclepias</i> family should be kept as a differential diagnosis in cases of acute corneal toxicity.</p>","PeriodicalId":46347,"journal":{"name":"Open Ophthalmology Journal","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2017-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/5b/TOOPHTJ-11-1.PMC5362972.pdf","citationCount":"9","resultStr":"{\"title\":\"Corneal Toxicity Following Exposure to <i>Asclepias Tuberosa</i>.\",\"authors\":\"Lauge Hjorth Mikkelsen, Hassan Hamoudi, Cigdem Altuntas Gül, Steffen Heegaard\",\"doi\":\"10.2174/1874364101711010001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To present a case of corneal toxicity following exposure to milky plant latex from <i>Asclepias tuberosa.</i></p><p><strong>Methods: </strong>A 70-year-old female presented with blurred vision and pain in her left eye after handling an <i>Ascepias tuberosa</i>. Clinical examination revealed a corneal stromal oedema with small epithelial defects. The corneal endothelium was intact and folds in Descemets membrane were observed. The oedema was treated with chloramphenicol, dexamethasone and scopolamine.</p><p><strong>Results: </strong>The corneal oedema had appeared after corneal exposure to the plant, <i>Asclepias tuberosa</i>, whose latex contains cardenolides that inhibit the Na<sup>+</sup>/ K<sup>+</sup>-ATPase in the corneal endothelium. The oedema resolved after 96 hours. After nine months the best corrected visual acuity was 20/20.</p><p><strong>Conclusion: </strong>Corneal toxicity has previously been reported for plants of the <i>Asclepias</i> family. This is a rare case describing severe corneal toxicity caused by exposure to latex from <i>Asclepias tuberosa</i>. Handling of plants of the <i>Asclepias</i> family should be kept as a differential diagnosis in cases of acute corneal toxicity.</p>\",\"PeriodicalId\":46347,\"journal\":{\"name\":\"Open Ophthalmology Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2017-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/5b/TOOPHTJ-11-1.PMC5362972.pdf\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Ophthalmology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874364101711010001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Ophthalmology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874364101711010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Corneal Toxicity Following Exposure to Asclepias Tuberosa.
Purpose: To present a case of corneal toxicity following exposure to milky plant latex from Asclepias tuberosa.
Methods: A 70-year-old female presented with blurred vision and pain in her left eye after handling an Ascepias tuberosa. Clinical examination revealed a corneal stromal oedema with small epithelial defects. The corneal endothelium was intact and folds in Descemets membrane were observed. The oedema was treated with chloramphenicol, dexamethasone and scopolamine.
Results: The corneal oedema had appeared after corneal exposure to the plant, Asclepias tuberosa, whose latex contains cardenolides that inhibit the Na+/ K+-ATPase in the corneal endothelium. The oedema resolved after 96 hours. After nine months the best corrected visual acuity was 20/20.
Conclusion: Corneal toxicity has previously been reported for plants of the Asclepias family. This is a rare case describing severe corneal toxicity caused by exposure to latex from Asclepias tuberosa. Handling of plants of the Asclepias family should be kept as a differential diagnosis in cases of acute corneal toxicity.
期刊介绍：
The Open Ophthalmology Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of experimental and clinical research in ophthalmology, including use of ophthalmological therapies, devices and surgical techniques. The Open Ophthalmology Journal, a peer-reviewed journal, is an important and reliable source of current information on developments in the field. The emphasis will be on publishing quality papers rapidly and making them freely available to researchers worldwide.
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