瘦素，神经炎症和肥胖。

2区医学 Q2 Medicine

Frontiers of Hormone Research Pub Date : 2017-01-01 Epub Date: 2017-02-28 DOI:10.1159/000452908

Nathalia R V Dragano, Roberta Haddad-Tovolli, Licio A Velloso

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引用次数: 27

摘要

下丘脑对瘦素的脂肪行为的抵抗是肥胖的一个标志。研究表明，由于摄入大量膳食脂肪而引发的下丘脑炎症是瘦素抵抗发展的重要机制。在本章中，我们将回顾为连接下丘脑神经炎症和肥胖中瘦素作用缺陷铺平道路的工作。

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Leptin, Neuroinflammation and Obesity.

Hypothalamic resistance to adipostatic actions of leptin is a hallmark of obesity. Studies have revealed that hypothalamic inflammation, triggered in response to the consumption of large amounts of dietary fat, is an important mechanism in the development of leptin resistance. In this chapter, we will review the work that paved the way linking neuroinflammation of the hypothalamus and defective leptin action in obesity.

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来源期刊

Frontiers of Hormone Research 医学-内分泌学与代谢

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期刊介绍： A series of integrated overviews on cutting-edge topics New sophisticated technologies and methodological approaches in diagnostics and therapeutics have led to significant improvements in identifying and characterizing an increasing number of medical conditions, which is particularly true for all aspects of endocrine and metabolic dysfunctions. Novel insights in endocrine physiology and pathophysiology allow for new perspectives in clinical management and thus lead to the development of molecular, personalized treatments. In view of this, the active interplay between basic scientists and clinicians has become fundamental, both to provide patients with the most appropriate care and to advance future research.