远距离缺血预处理对急性术后疼痛镇痛作用的临床实验模型研究。

Q2 Medicine
Pain Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-06-30 DOI:10.1155/2016/5093870
Francisco Elano Carvalho Pereira, Irene Lopes Mello, Fernando Heladio de Oliveira Medeiros Pimenta, Debora Maia Costa, Deysi Viviana Tenazoa Wong, Claudia Regina Fernandes, Roberto César Lima Junior, Josenília M Alves Gomes
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引用次数: 8

摘要

本研究旨在评估远程缺血预处理(RIPC)临床模型的可行性及其镇痛效果。本研究为前瞻性研究,20例患者随机分为两组:对照组和RIPC组。观察两组患者术后阿片类镇痛药用量、继发性机械性痛觉过敏情况、术后疼痛视觉模拟评分及血浆白细胞介素(IL-6)水平。在脊髓麻醉阻滞后使用止血带是安全的,止血带组所有患者均无疼痛。RIPC组24 h吗啡总用量显著低于对照组(p = 0.0156)。静息痛、咳嗽痛和深呼吸痛的强度分析显示,RIPC组视觉模拟评分(VAS)明显低于对照组,p值分别为0.0087、0.0119和0.0015。两组在有无机械性痛觉过敏的分析中无差异(p = 0.0704),血清IL-6剂量随时间变化的水平无差异(p < 0.0001)。该远程缺血预处理临床模型在常规胆囊切除术患者中促进了满意的镇痛,且未改变血清IL-6水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Clinical Experimental Model to Evaluate Analgesic Effect of Remote Ischemic Preconditioning in Acute Postoperative Pain.

A Clinical Experimental Model to Evaluate Analgesic Effect of Remote Ischemic Preconditioning in Acute Postoperative Pain.

A Clinical Experimental Model to Evaluate Analgesic Effect of Remote Ischemic Preconditioning in Acute Postoperative Pain.

A Clinical Experimental Model to Evaluate Analgesic Effect of Remote Ischemic Preconditioning in Acute Postoperative Pain.

This study aims to evaluate the viability of a clinical model of remote ischemic preconditioning (RIPC) and its analgesic effects. It is a prospective study with twenty (20) patients randomly divided into two groups: control group and RIPC group. The opioid analgesics consumption in the postoperative period, the presence of secondary mechanical hyperalgesia, the scores of postoperative pain by visual analog scale, and the plasma levels interleukins (IL-6) were evaluated. The tourniquet applying after spinal anesthetic block was safe, producing no pain for all patients in the tourniquet group. The total dose of morphine consumption in 24 hours was significantly lower in RIPC group than in the control group (p = 0.0156). The intensity analysis of rest pain, pain during coughing and pain in deep breathing, showed that visual analogue scale (VAS) scores were significantly lower in RIPC group compared to the control group: p = 0.0087, 0.0119, and 0.0015, respectively. There were no differences between groups in the analysis of presence or absence of mechanical hyperalgesia (p = 0.0704) and in the serum levels of IL-6 dosage over time (p < 0.0001). This clinical model of remote ischemic preconditioning promoted satisfactory analgesia in patients undergoing conventional cholecystectomy, without changing serum levels of IL-6.

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来源期刊
Pain Research and Treatment
Pain Research and Treatment Medicine-Anesthesiology and Pain Medicine
CiteScore
3.60
自引率
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