{"title":"基因组重编程的几何控制和建模。","authors":"Caroline Uhler, G V Shivashankar","doi":"10.1080/19490992.2016.1201620","DOIUrl":null,"url":null,"abstract":"<p><p>Cell geometry is tightly coupled to gene expression patterns within the tissue microenvironment. This perspective synthesizes evidence that the 3D organization of chromosomes is a critical intermediate for geometric control of genomic programs. Using a combination of experiments and modeling we outline approaches to decipher the mechano-genomic code that governs cellular homeostasis and reprogramming. </p>","PeriodicalId":89329,"journal":{"name":"Bioarchitecture","volume":"6 4","pages":"76-84"},"PeriodicalIF":0.0000,"publicationDate":"2016-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19490992.2016.1201620","citationCount":"15","resultStr":"{\"title\":\"Geometric control and modeling of genome reprogramming.\",\"authors\":\"Caroline Uhler, G V Shivashankar\",\"doi\":\"10.1080/19490992.2016.1201620\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cell geometry is tightly coupled to gene expression patterns within the tissue microenvironment. This perspective synthesizes evidence that the 3D organization of chromosomes is a critical intermediate for geometric control of genomic programs. Using a combination of experiments and modeling we outline approaches to decipher the mechano-genomic code that governs cellular homeostasis and reprogramming. </p>\",\"PeriodicalId\":89329,\"journal\":{\"name\":\"Bioarchitecture\",\"volume\":\"6 4\",\"pages\":\"76-84\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/19490992.2016.1201620\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioarchitecture\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/19490992.2016.1201620\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2016/7/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioarchitecture","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/19490992.2016.1201620","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/7/19 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Geometric control and modeling of genome reprogramming.
Cell geometry is tightly coupled to gene expression patterns within the tissue microenvironment. This perspective synthesizes evidence that the 3D organization of chromosomes is a critical intermediate for geometric control of genomic programs. Using a combination of experiments and modeling we outline approaches to decipher the mechano-genomic code that governs cellular homeostasis and reprogramming.
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