缺电子酚的高效o -三氟甲基化的流动电合成

IF 4.7 3区工程技术 Q2 ELECTROCHEMISTRY

Electrochemistry Communications Pub Date : 2023-09-01 DOI:10.1016/j.elecom.2023.107545

Johannes Bernd, Andreas Terfort

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引用次数: 0

摘要

提出了一种将电化学合成与流动技术相结合的o -三氟甲基化贫电子酚的可持续策略。通过筛选实验对反应进行优化，建立了快速高效的流动方案。朗格卢瓦试剂和苯酚在微流池中同时阳极氧化，可直接制备三氟甲基醚，收率高达90%。该一步法对多种官能团具有良好的耐受性，具有良好的区域选择性，并且不需要任何化学氧化剂和催化剂，使用电流作为一种廉价和可持续的试剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Flow electrosynthesis for efficient O-trifluoromethylation of electron-deficient phenols

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Flow electrosynthesis for efficient O-trifluoromethylation of electron-deficient phenols

A sustainable strategy for O-trifluoromethylation of electron-deficient phenols by combining electrochemical synthesis with flow technology is presented. The reaction is optimized by screening experiments to establish a fast and efficient flow protocol. Simultaneous anodic oxidation of Langlois reagent and the phenols in a micro flow cell leads to direct preparation of trifluoromethyl ethers in yields up to 90%. This one-step protocol is tolerant of several functional groups, shows good regioselectivity and works without any chemical oxidants and catalysts by using electrical current as an inexpensive and sustainable reagent.

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来源期刊

Electrochemistry Communications 工程技术-电化学

CiteScore

8.50

自引率

3.70%

发文量

160

审稿时长

1.2 months

期刊介绍： Electrochemistry Communications is an open access journal providing fast dissemination of short communications, full communications and mini reviews covering the whole field of electrochemistry which merit urgent publication. Short communications are limited to a maximum of 20,000 characters (including spaces) while full communications and mini reviews are limited to 25,000 characters (including spaces). Supplementary information is permitted for full communications and mini reviews but not for short communications. We aim to be the fastest journal in electrochemistry for these types of papers.