围术期注射Lucentis对增殖性糖尿病视网膜病变患者术中出血影响的meta分析。

眼科学报 Pub Date : 2015-12-01

Guoqi Guan, Jing Zang

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引用次数: 0

摘要

背景:采用meta分析系统评价围手术期注射Lucentis对增殖性糖尿病视网膜病变(PDR)患者术中出血的影响。方法:纳入Medline、Cochrane图书馆、PubMed、中国生物医学文献数据库和中国学术期刊全文数据库中有关围手术期玻璃体内注射和不注射Lucentis的眼科手术治疗报告。对所有纳入的文献进行meta分析。在上述数据库中进行了计算机搜索。此外，还手工检索了相关书籍、期刊和会议记录及其参考书目。根据纳入和排除标准筛选已发表的文献。对纳入的研究进行数据提取。采用RevMan5.2软件进行统计分析。二分类变量以比值比(ORs)和95%置信区间(ci)表示。主要指标为玻璃体切除术中视网膜出血的发生情况。结果:共纳入7项研究。治疗组159眼，对照组149眼。治疗组(围术期注射Lucentis)术中出血量显著低于对照组(OR, 56.93;95% ci: 21.81 ~ 148.57, p < 0.01)。结论:玻璃体切除术前玻璃体内注射Lucentis可显著减少PDR患者术中出血。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Meta-analysis of the effect of perioperative injection of Lucentis on intraoperative bleeding in patients with proliferative diabetic retinopathy.

Background: The effect of perioperative injection of Lucentis on intraoperative bleeding in patients with proliferative diabetic retinopathy (PDR) was systematically evaluated using a meta-analysis.

Methods: Reports of surgical eye treatment with and without perioperative intravitreal injection of Lucentis in Medline, the Cochrane Library, PubMed, the Chinese Biomedical Literature Database, and China Academic Journals Full-text Database were included in the study. A meta-analysis was performed on all included literature. A computerized search was performed in the above databases. In addition, relevant books, journals, and conference proceedings and their bibliographies were manually searched. Published literature was screened according to the inclusion and exclusion criteria. Data extraction was performed on included studies. RevMan5.2 software was used for the statistical analyses. Dichotomous variables are presented as odds ratios (ORs) and 95% confidence intervals (CIs). The major indicator was the occurrence of intraoperative retinal hemorrhaging during vitrectomy.

Results: A total of seven studies were included in the analysis. The treatment group included 159 eyes and control group included 149 eyes. The amount of intraoperative bleeding in the treatment group (perioperative Lucentis injection) was significantly lower than that in the control group (OR, 56.93; 95% CI: 21.81-148.57, P < 0.01).

Conclusions: Intravitreal Lucentis injection before a vitrectomy significantly reduced intraoperative bleeding in PDR patients.

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来源期刊

眼科学报

自引率

0.00%

发文量

1312

期刊介绍： Eye science was founded in 1985. It is a national medical journal supervised by the Ministry of Education of the People's Republic of China, sponsored by Sun Yat-sen University, and hosted by Sun Yat-sen University Zhongshan Eye Center (in October 2020, it was changed from a quarterly to a monthly, with the publication number: ISSN: 1000-4432; CN: 44-1119/R). It is edited by Ge Jian, former dean of Sun Yat-sen University Zhongshan Eye Center, Liu Yizhi, director and dean of Sun Yat-sen University Zhongshan Eye Center, and Lin Haotian, deputy director of Sun Yat-sen University Zhongshan Eye Center, as executive editor. It mainly reports on new developments and trends in the field of ophthalmology at home and abroad, focusing on basic research in ophthalmology, clinical experience, and theoretical knowledge and technical operations related to epidemiology. It has been included in important databases at home and abroad, such as Chemical Abstract (CA), China Journal Full-text Database (CNKI), China Core Journals (Selection) Database (Wanfang), and Chinese Science and Technology Journal Database (VIP).