BDNF DNA甲基化变化作为精神疾病的生物标志物:文献综述和开放获取数据库分析

IF 4.7 2区心理学 Q1 BEHAVIORAL SCIENCES

Behavioral and Brain Functions Pub Date : 2016-06-06 DOI:10.1186/s12993-016-0101-4

Galina Y Zheleznyakova, Hao Cao, Helgi B Schiöth

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引用次数: 91

摘要

脑源性神经营养因子(Brain-derived neurotrophic factor, BDNF)在神经系统的发育和功能中起着重要的作用，已经证实BDNF参与了许多精神疾病的发病机制。最近，许多研究将BDNF启动子的DNA甲基化水平与某些精神表型联系起来。在这篇综述中，我们总结了当前文献中的数据以及我们自己对BDNF甲基化变化与精神疾病的相关性的分析，并提出了与BDNF相关的DNA甲基化是否可以作为特定神经精神疾病的生物标志物的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis.

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BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis.

Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders.

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来源期刊

Behavioral and Brain Functions 医学-行为科学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.