吗啡栓剂与吲哚美辛栓剂治疗肾绞痛的随机临床试验。

Q2 Medicine
Pain Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-03-17 DOI:10.1155/2016/4981585
Forough Zamanian, Mohammad Jalili, Maziar Moradi-Lakeh, Maryam Kia, Rokhsareh Aghili, Seyed Mojtaba Aghili
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引用次数: 10

摘要

背景。肾绞痛是一种医疗紧急情况,由于其快速发作和毁灭性的性质的痛苦。阿片类药物和非甾体抗炎药(NSAIDs)都是治疗的一线选择。的目标。本研究旨在比较阿片类药物和非甾体抗炎药治疗急性肾绞痛的疗效和安全性。方法。158例患者分为两组(n = 79),分别给予10mg吗啡和100mg吲哚美辛栓剂。在基线和给药后20、40、60和90分钟使用口头数字评定量表测量疼痛的严重程度。同时记录药物副作用及患者生命体征。结果。在前20分钟内,吗啡栓剂组疼痛评分的平均下降幅度明显高于吗啡栓剂组。然而,在入院后的前40分钟、60分钟和90分钟内,两组疼痛评分的平均下降没有显著差异。两组患者药物副作用发生率及生命体征变化无明显差异。结论。与吲哚美辛相比,吗啡栓剂似乎在快速缓解疼痛方面更有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial.

Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial.

Morphine Suppository versus Indomethacin Suppository in the Management of Renal Colic: Randomized Clinical Trial.

Background. Renal colic is a medical emergency due to the rapid onset and devastating nature of its pain. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are both used as first-line choices in its management. Aim. This study aimed to compare the efficacy and safety of opioids and NSAIDs in the management of acute renal colic. Methods. One hundred and fifty-eight patients were divided into two groups (n = 79) and received either 10 mg morphine or 100 mg indomethacin suppositories. The severity of pain was measured using verbal numeric rating scale at baseline and 20, 40, 60, and 90 minutes after the administration of analgesics. Drug side effects as well as patients' vital signs were also recorded. Results. The mean decrease in the pain score during the first 20 minutes was significantly higher among those who received morphine suppository. However, no significant difference was observed between the two groups regarding the mean decrease in pain score during the first 40, 60, and 90 minutes after the admission. Prevalence of drug side effects or changes in the vital signs was not significantly different between the two groups. Conclusions. Morphine suppositories seem to be more efficient in achieving rapid pain relief comparing to indomethacin.

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来源期刊
Pain Research and Treatment
Pain Research and Treatment Medicine-Anesthesiology and Pain Medicine
CiteScore
3.60
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