儿童和青少年肥胖与颈动脉和股动脉僵硬度的压力依赖性和年龄相关性增加有关,而与肱动脉无关,这表明动脉壁发生了非内在性改变。

IF 2.5 Q2 PERIPHERAL VASCULAR DISEASE
International Journal of Vascular Medicine Pub Date : 2016-01-01 Epub Date: 2016-03-15 DOI:10.1155/2016/4916246
Victoria García-Espinosa, Santiago Curcio, Juan Manuel Castro, Maite Arana, Gustavo Giachetto, Pedro Chiesa, Yanina Zócalo, Daniel Bia
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引用次数: 0

摘要

目的分析儿童肥胖是否与弹性动脉、过渡动脉和/或肌肉动脉僵硬度的变化有关。方法。根据体重指数 Z 值,将 221 名受试者(4-15 岁,92 名女性)分为正常体重组(NW,n = 137)和肥胖组(OB,n = 84)。年龄组定义如下4-8岁;8-12岁;12-15岁。通过收缩舒张压-直径和应力-应变关系确定颈动脉、股动脉和肱动脉的局部僵硬度。为此,记录了动脉直径、外周和主动脉血压(BP)水平和波形。测定颈动脉-股动脉、股动脉-桡动脉和颈动脉-桡动脉脉搏波速度,以分别评估主动脉、下肢和上肢区域动脉僵硬度。对动脉僵化参数与血压之间的相关性进行了分析。结果显示与白细胞相比,卵巢癌受试者的外周和中心血压以及颈动脉和股动脉僵化程度较高,在 12 岁及以上的受试者中达到统计学意义。当血压水平正常化后,动脉僵化差异消失。内在动脉壁僵硬度(弹性模量)、血压僵硬度关系和区域僵硬度参数没有差异。结论:OB 与血压相关。骨质疏松与血压有关,颈动脉和股动脉(而非肱动脉)僵硬度的增加与年龄有关。动脉壁的内在变化无法解释僵硬度的变化,但可能与肥胖儿童血压水平较高有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries' Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration.

Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries' Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration.

Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries' Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration.

Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries' Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration.

Aim. To analyze if childhood obesity associates with changes in elastic, transitional, and/or muscular arteries' stiffness. Methods. 221 subjects (4-15 years, 92 females) were assigned to normal weight (NW, n = 137) or obesity (OB, n = 84) groups, considering their body mass index z-score. Age groups were defined: 4-8; 8-12; 12-15 years old. Carotid, femoral, and brachial artery local stiffness was determined through systodiastolic pressure-diameter and stress-strain relationships. To this end, arterial diameter and peripheral and aortic blood pressure (BP) levels and waveforms were recorded. Carotid-femoral, femoropedal, and carotid-radial pulse wave velocities were determined to evaluate aortic, lower-limb, and upper-limb regional arterial stiffness, respectively. Correlation analysis between stiffness parameters and BP was done. Results. Compared to NW, OB subjects showed higher peripheral and central BP and carotid and femoral stiffness, reaching statistical significance in subjects aged 12 and older. Arterial stiffness differences disappeared when levels were normalized for BP. There were no differences in intrinsic arterial wall stiffness (elastic modulus), BP stiffness relationships, and regional stiffness parameters. Conclusion. OB associates with BP-dependent and age-related increase in carotid and femoral (but not brachial) stiffness. Stiffness changes would not be explained by intrinsic arterial wall alterations but could be associated with the higher BP levels observed in obese children.

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来源期刊
International Journal of Vascular Medicine
International Journal of Vascular Medicine PERIPHERAL VASCULAR DISEASE-
CiteScore
3.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
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