小鼠视网膜祖细胞的时间同一性调节机制。

Neurogenesis (Austin, Tex.) Pub Date : 2015-12-15 eCollection Date: 2015-01-01 DOI:10.1080/23262133.2015.1125409
Pierre Mattar, Michel Cayouette
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引用次数: 15

摘要

虽然近年来在阐明控制神经祖细胞如何在特定空间域中产生各种胶质细胞和神经细胞类型的转录因子编码方面取得了很大进展,但对于这些祖细胞如何随时间改变其输出却知之甚少。在过去的几年里,对发育中的小鼠视网膜的研究提供了证据,表明类似于果蝇神经母细胞的转录级联可能控制脊椎动物的祖细胞时间同一性。据报道,锌指转录因子Ikzf1 (Ikaros)是驼背果蝇的同源基因,在视网膜祖细胞中赋予了早期时间身份。最近,人们发现,驼背果蝇的同源基因Casz1作为中晚期时间身份因子发挥作用,受Ikzf1的负调控。然而,这些时间同一性因子在视网膜祖细胞中起作用的分子机制仍然未知。在这里,我们简要回顾了以前的工作在脊椎动物视网膜的时间身份因素,并提出了一个模型,通过他们可能运作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mechanisms of temporal identity regulation in mouse retinal progenitor cells.

Mechanisms of temporal identity regulation in mouse retinal progenitor cells.

While much progress has been made in recent years toward elucidating the transcription factor codes controlling how neural progenitor cells generate the various glial and neuronal cell types in a particular spatial domain, much less is known about how these progenitors alter their output over time. In the past years, work in the developing mouse retina has provided evidence that a transcriptional cascade similar to the one used in Drosophila neuroblasts might control progenitor temporal identity in vertebrates. The zinc finger transcription factor Ikzf1 (Ikaros), an ortholog of Drosophila hunchback, was reported to confer early temporal identity in retinal progenitors and, more recently, the ortholog of Drosophila castor, Casz1, was found to function as a mid/late temporal identity factor that is negatively regulated by Ikzf1. The molecular mechanisms by which these temporal identity factors function in retinal progenitors, however, remain unknown. Here we briefly review previous work on the vertebrate temporal identity factors in the retina, and propose a model by which they might operate.

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