{"title":"炎症功能障碍和疾病的早期生活环境和发育免疫毒性。","authors":"Cynthia A Leifer, Rodney R Dietert","doi":"10.1080/02772248.2011.586114","DOIUrl":null,"url":null,"abstract":"<p><p>Components of the innate immune system such as macrophages and dendritic cells are instrumental in determining the fate of immune responses and are, also, among the most sensitive targets of early life environmental alterations including developmental immunotoxicity (DIT). DIT can impede innate immune cell maturation, disrupt tissue microenvironment, alter immune responses to infectious challenges, and disrupt regulatory responses. Dysregulation of inflammation, such as that observed with DIT, has been linked with an increased risk of chronic inflammatory diseases in both children and adults. In this review, we discuss the relationship between early-life risk factors for innate immune modulation and promotion of dysregulated inflammation associated with chronic inflammatory disease. The health risks from DIT-associated inflammation may extend beyond primary immune dysfunction to include an elevated risk of several later-life, inflammatory-mediated diseases that target a wide range of physiological systems and organs. For this reason, determination of innate immune status should be an integral part of drug and chemical safety evaluation.</p>","PeriodicalId":23122,"journal":{"name":"Toxicological and Environmental Chemistry","volume":"93 7","pages":"1463-1485"},"PeriodicalIF":1.1000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486307/pdf/nihms-693115.pdf","citationCount":"0","resultStr":"{\"title\":\"Early life environment and developmental immunotoxicity in inflammatory dysfunction and disease.\",\"authors\":\"Cynthia A Leifer, Rodney R Dietert\",\"doi\":\"10.1080/02772248.2011.586114\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Components of the innate immune system such as macrophages and dendritic cells are instrumental in determining the fate of immune responses and are, also, among the most sensitive targets of early life environmental alterations including developmental immunotoxicity (DIT). DIT can impede innate immune cell maturation, disrupt tissue microenvironment, alter immune responses to infectious challenges, and disrupt regulatory responses. Dysregulation of inflammation, such as that observed with DIT, has been linked with an increased risk of chronic inflammatory diseases in both children and adults. In this review, we discuss the relationship between early-life risk factors for innate immune modulation and promotion of dysregulated inflammation associated with chronic inflammatory disease. The health risks from DIT-associated inflammation may extend beyond primary immune dysfunction to include an elevated risk of several later-life, inflammatory-mediated diseases that target a wide range of physiological systems and organs. For this reason, determination of innate immune status should be an integral part of drug and chemical safety evaluation.</p>\",\"PeriodicalId\":23122,\"journal\":{\"name\":\"Toxicological and Environmental Chemistry\",\"volume\":\"93 7\",\"pages\":\"1463-1485\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2011-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486307/pdf/nihms-693115.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxicological and Environmental Chemistry\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1080/02772248.2011.586114\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicological and Environmental Chemistry","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1080/02772248.2011.586114","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
先天性免疫系统的组成部分,如巨噬细胞和树突状细胞,在决定免疫反应的命运方面起着重要作用,同时也是生命早期环境变化(包括发育免疫毒性(DIT))最敏感的目标之一。发育免疫毒性会阻碍先天性免疫细胞的成熟,破坏组织微环境,改变对感染性挑战的免疫反应,并扰乱调节反应。炎症失调(如在 DIT 中观察到的情况)与儿童和成人患慢性炎症性疾病的风险增加有关。在这篇综述中,我们将讨论先天性免疫调节的早期生活风险因素与促进与慢性炎症性疾病相关的炎症失调之间的关系。与先天性免疫失调相关的炎症对健康的危害可能超出了原发性免疫功能失调的范围,还包括日后患上多种炎症介导疾病的风险升高,这些疾病主要针对各种生理系统和器官。因此,先天性免疫状态的测定应成为药物和化学品安全性评估的一个组成部分。
Early life environment and developmental immunotoxicity in inflammatory dysfunction and disease.
Components of the innate immune system such as macrophages and dendritic cells are instrumental in determining the fate of immune responses and are, also, among the most sensitive targets of early life environmental alterations including developmental immunotoxicity (DIT). DIT can impede innate immune cell maturation, disrupt tissue microenvironment, alter immune responses to infectious challenges, and disrupt regulatory responses. Dysregulation of inflammation, such as that observed with DIT, has been linked with an increased risk of chronic inflammatory diseases in both children and adults. In this review, we discuss the relationship between early-life risk factors for innate immune modulation and promotion of dysregulated inflammation associated with chronic inflammatory disease. The health risks from DIT-associated inflammation may extend beyond primary immune dysfunction to include an elevated risk of several later-life, inflammatory-mediated diseases that target a wide range of physiological systems and organs. For this reason, determination of innate immune status should be an integral part of drug and chemical safety evaluation.
期刊介绍:
The journal is interdisciplinary in outlook, and manuscripts published in it cover all relevant areas: • inorganic chemistry – trace elements in food and the environment, metal complexes and chelates; • organic chemistry – environmental fate, chemical reactions, metabolites and secondary products, synthesis of standards and labelled materials; • physical chemistry – photochemistry, radiochemistry; • environmental chemistry – sources, fate, and sinks of xenochemicals, environmental partitioning and transport, degradation and deposition; • analytical chemistry – development and optimisation of analytical methods, instrumental and methodological advances, miniaturisation and automation; • biological chemistry – pharmacology and toxicology, uptake, metabolism, disposition of xenochemicals, structure-activity relationships, modes of action, ecotoxicological testing.