视网膜神经纤维层厚度及视盘OCT测量在青光眼早期诊断中的作用。

眼科学报 Pub Date : 2015-03-01

Zanmei Hua, Qiuyun Fang, Xiangyin Sha, Ruiming Yang, Zuopeng Hong

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引用次数: 0

摘要

目的:青光眼是一种眼病，可导致不可逆的视神经损伤并导致失明。光学相干断层扫描(OCT)可以通过测量视网膜神经纤维和视盘参数来早期诊断青光眼。回顾性分析光谱域OCT测量视网膜神经纤维层(RNFL)厚度和视盘断层扫描对疑似青光眼和原发性开角型青光眼(POAG)早期诊断的影响。方法:临床病例-对照研究。采用oct测量对照组(n = 51、98眼)、疑似青光眼组(n = 81、146眼)和POAG组(n = 55、106眼)视盘周围RNFL厚度和视盘断层成像参数，参数包括上、下、鼻、颞部平均RNFL厚度、椎间盘面积(DA)、杯面积(CA)、边缘面积(RA)、椎间盘体积(DV)、杯体积(CV)、边缘体积(RV)、杯/盘面积比(CA/DA)、边缘/盘面积比(RA/DA)、杯/盘体积比(CV/DV)和圈/盘体积比(RV/DV)。结果:经单因素方差分析，三组间RNFL参数、DA、CA、RA、DV、CV、CA/DA、RA/DA、CV/DV和RV/DV均有显著差异。对照组和POAG组的下侧和颞侧RNFL厚度差异显著。三组间RV无显著性差异。POAG组RNFL平均厚度的最大ROC曲线下面积(AROC)为0.845。视盘参数的最大AROC为RA/DA(0.998)，其次为CA/DA(0.997)。CA、RA、CV、DV的AROC均> 0.900。结论:OCT可作为鉴别疑似青光眼与POAG的有效诊断手段。

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Role of Retinal Nerve Fiber Layer Thickness and Optic Disk Measurement by OCT on Early Diagnosis of Glaucoma.

Purpose: Glaucoma is an eye disease that can lead to irreversible optic nerve damage and cause blindness. Optical coherence tomography (OCT) allows an early diagnosis of glaucoma by the measurements of the retinal nerve fiber and optic disc parameters. A retrospective study was designed to analyze the effects of the measurement of the retinal nerve fiber layer (RNFL) thickness and the optic disc tomography by spectral-domain OCT on the early diagnosis of suspected glaucoma and primary open angle glaucoma (POAG).

Methods: This was a clinical case-control study. The RNFL thickness around the optic disc and optic disk tomographic parameters of the control (n = 51, 98 eyes), suspected glaucoma (n = 81, 146 eyes), and POAG groups (n = 55, 106 eyes) were measured by OCT. The parameters included superior, inferior, nasal and temporal mean RNFL thickness, disc area (DA), cup area (CA), rim area (RA), disc volume (DV), cup volume (CV), rim volume (RV), cup/disc area ratio (CA/DA), rim/disc area ratio (RA/DA), cup/disc volume ratio (CV/DV) and rim/disc volume ratio (RV/DV).

Results: Superior, nasal, and mean RNFL parameters, DA, CA,RA, DV, CV, CA/DA, RA/DA, CV/DV and RV/DV significantly differed among three groups by single-factorial ANOVA. Inferior and temporal RNFL thickness significantly differed between the control and POAG groups. No significant difference was observed in RV among three groups. In the POAG group, the maximum area under the ROC curve (AROC) of mean RNFL thickness was 0.845. The maximum AROC of optic disk parameters was RA/DA (0.998), followed by CA/DA (0.997). The AROC of CA, RA, CV, and DV were all > 0.900.

Conclusion: OCT may serve as a useful diagnostic modality in distinguishing suspected glaucoma from POAG.

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来源期刊

眼科学报

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发文量

1312

期刊介绍： Eye science was founded in 1985. It is a national medical journal supervised by the Ministry of Education of the People's Republic of China, sponsored by Sun Yat-sen University, and hosted by Sun Yat-sen University Zhongshan Eye Center (in October 2020, it was changed from a quarterly to a monthly, with the publication number: ISSN: 1000-4432; CN: 44-1119/R). It is edited by Ge Jian, former dean of Sun Yat-sen University Zhongshan Eye Center, Liu Yizhi, director and dean of Sun Yat-sen University Zhongshan Eye Center, and Lin Haotian, deputy director of Sun Yat-sen University Zhongshan Eye Center, as executive editor. It mainly reports on new developments and trends in the field of ophthalmology at home and abroad, focusing on basic research in ophthalmology, clinical experience, and theoretical knowledge and technical operations related to epidemiology. It has been included in important databases at home and abroad, such as Chemical Abstract (CA), China Journal Full-text Database (CNKI), China Core Journals (Selection) Database (Wanfang), and Chinese Science and Technology Journal Database (VIP).