HCV/HIV合并感染的自然史和治疗:是时候改变模式了吗?

IF 26.8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Journal of Hepatology Pub Date : 2015-11-01 DOI:10.1016/j.jhep.2015.06.034

Joop E. Arends , Faydra I. Lieveld , Lauke L. Boeijen , Clara T.M.M. de Kanter , Karel J. van Erpecum , Dominique Salmon , Andy I.M. Hoepelman , Tarik Asselah , Andrew Ustianowski

{"title":"HCV/HIV合并感染的自然史和治疗:是时候改变模式了吗?","authors":"Joop E. Arends , Faydra I. Lieveld , Lauke L. Boeijen , Clara T.M.M. de Kanter , Karel J. van Erpecum , Dominique Salmon , Andy I.M. Hoepelman , Tarik Asselah , Andrew Ustianowski","doi":"10.1016/j.jhep.2015.06.034","DOIUrl":null,"url":null,"abstract":"<div><p><span>Evidence over the past decades have shown that HIV/HCV coinfected patients did not respond as well to HCV<span> therapy as HCV mono-infected patients. However, these paradigms are being recently reassessed with the improvements of care for HIV and HCV patients. This article reviews these original paradigms and how the new data is impacting upon them. Treatment efficacy now appears comparable for HIV/HCV coinfected and HCV mono-infected patients, while liver fibrosis progression is increasingly similar in optimally managed patients. Additional importance of therapy is directed to drug-drug interactions and the impact of HCV reinfection, as well as the possibility of transmitted </span></span>drug resistance.</p></div>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"63 5","pages":"Pages 1254-1262"},"PeriodicalIF":26.8000,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jhep.2015.06.034","citationCount":"53","resultStr":"{\"title\":\"Natural history and treatment of HCV/HIV coinfection: Is it time to change paradigms?\",\"authors\":\"Joop E. Arends , Faydra I. Lieveld , Lauke L. Boeijen , Clara T.M.M. de Kanter , Karel J. van Erpecum , Dominique Salmon , Andy I.M. Hoepelman , Tarik Asselah , Andrew Ustianowski\",\"doi\":\"10.1016/j.jhep.2015.06.034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Evidence over the past decades have shown that HIV/HCV coinfected patients did not respond as well to HCV<span> therapy as HCV mono-infected patients. However, these paradigms are being recently reassessed with the improvements of care for HIV and HCV patients. This article reviews these original paradigms and how the new data is impacting upon them. Treatment efficacy now appears comparable for HIV/HCV coinfected and HCV mono-infected patients, while liver fibrosis progression is increasingly similar in optimally managed patients. Additional importance of therapy is directed to drug-drug interactions and the impact of HCV reinfection, as well as the possibility of transmitted </span></span>drug resistance.</p></div>\",\"PeriodicalId\":15888,\"journal\":{\"name\":\"Journal of Hepatology\",\"volume\":\"63 5\",\"pages\":\"Pages 1254-1262\"},\"PeriodicalIF\":26.8000,\"publicationDate\":\"2015-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jhep.2015.06.034\",\"citationCount\":\"53\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hepatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0168827815004626\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hepatology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0168827815004626","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 53

摘要

过去几十年的证据表明，HIV/HCV合并感染患者对HCV治疗的反应不如HCV单一感染患者。然而，随着对艾滋病毒和丙型肝炎患者护理的改善，最近正在对这些范例进行重新评估。本文回顾了这些原始范例，以及新数据如何影响它们。目前，HIV/HCV合并感染和HCV单一感染患者的治疗效果似乎相当，而在优化管理的患者中，肝纤维化的进展越来越相似。治疗的另一个重要性是针对药物-药物相互作用和丙型肝炎病毒再感染的影响，以及传播耐药性的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Natural history and treatment of HCV/HIV coinfection: Is it time to change paradigms?

Evidence over the past decades have shown that HIV/HCV coinfected patients did not respond as well to HCV therapy as HCV mono-infected patients. However, these paradigms are being recently reassessed with the improvements of care for HIV and HCV patients. This article reviews these original paradigms and how the new data is impacting upon them. Treatment efficacy now appears comparable for HIV/HCV coinfected and HCV mono-infected patients, while liver fibrosis progression is increasingly similar in optimally managed patients. Additional importance of therapy is directed to drug-drug interactions and the impact of HCV reinfection, as well as the possibility of transmitted drug resistance.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Hepatology 医学-胃肠肝病学

CiteScore

46.10

自引率

4.30%

发文量

2325

审稿时长

30 days

期刊介绍： The Journal of Hepatology is the official publication of the European Association for the Study of the Liver (EASL). It is dedicated to presenting clinical and basic research in the field of hepatology through original papers, reviews, case reports, and letters to the Editor. The Journal is published in English and may consider supplements that pass an editorial review.