联合PTCy和ATG预防非恶性疾病的GvHD

IF 6.9 2区医学 Q1 HEMATOLOGY

Blood Reviews Pub Date : 2023-11-01 DOI:10.1016/j.blre.2022.101016

Amy E. DeZern , Robert A. Brodsky

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引用次数: 3

摘要

骨髓移植治疗非恶性疾病，如再生障碍性贫血和血红蛋白病是一个新兴的临床领域。这些移植的目的是在尽可能减少毒性的情况下纠正造血缺陷。这需要减轻移植特异性毒性，如移植物抗宿主病，因为在非恶性疾病中不需要这样做。本综述详细介绍了该领域目前的临床结果，重点关注移植后环磷酰胺和抗胸腺球蛋白作为强化移植物抗宿主病预防以实现这一目标。

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Combining PTCy and ATG for GvHD prophylaxis in non-malignant diseases

Bone marrow transplantation for non-malignant diseases such as aplastic anemia and hemoglobinopathies is a burgeoning clinical area. The goal of these transplants is to correct the hematopoietic defect with as little toxicity as possible. This requires mitigation of transplant-specific toxicities such as graft versus host disease, given this is not needed in non-malignant disorders. This review details current clinical outcomes in the field with a focus on post-transplantation cyclophosphamide and anti-thymoglobulin as intensive graft versus host disease prophylaxis to achieve that goal.

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来源期刊

Blood Reviews 医学-血液学

CiteScore

13.80

自引率

1.40%

发文量

期刊介绍： Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.