在夏威夷奥胡岛,地下水含水层中的钒增加了MAC肺部感染的风险。

IF 3.3 Q2 ENVIRONMENTAL SCIENCES
Environmental Epidemiology Pub Date : 2022-09-02 eCollection Date: 2022-10-01 DOI:10.1097/EE9.0000000000000220
Ettie M Lipner, Joshua P French, Stephen Nelson, Joseph O Falkinham Iii, Rachel A Mercaldo, Rebekah A Blakney, Yihe G Daida, Timothy B Frankland, Kyle P Messier, Jennifer R Honda, Stacey Honda, D Rebecca Prevots
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引用次数: 4

摘要

夏威夷是非结核分枝杆菌(NTM)肺病在美国的发病率最高。先前的研究表明,地表水中的某些微量金属增加了NTM感染的风险。目的:了解夏威夷奥胡岛地区微量金属对NTM感染风险的影响。方法:利用2005-2019年在夏威夷凯撒医疗机构登记的患者的NTM感染发生率数据进行了一项基于人群的生态队列研究。我们获得了所有Kaiser Permanente夏威夷受益人的社会人口学、微生物学和地理编码的居住数据。为了估计地下水成分暴露导致NTM肺部感染的风险,我们从三个数据源获取了地下水数据:(1)水质门户;(2)夏威夷卫生部;(3)杨百翰大学地质科学系。数据按含水层汇总,并与相应的受益居住含水层相关联。我们使用带反向消去的泊松回归模型生成了NTM感染风险随地下水成分变化的模型。我们模拟了两种结果:鸟分枝杆菌复合体(MAC)种和脓肿分枝杆菌群种。结果:在含水层水平,地下水中钒的对数浓度每增加1个单位,MAC患者感染风险增加22%。我们没有观察到水质成分与脓肿分枝杆菌患者感染风险之间的显著关联。结论:夏威夷奥胡岛地下水中钒浓度与MAC肺部感染有关。这些发现提供了证据,证明天然存在的微量金属影响了市政供水系统水源中NTM的存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vanadium in groundwater aquifers increases the risk of MAC pulmonary infection in O'ahu, Hawai'i.

Hawai'i has the highest prevalence of nontuberculous mycobacterial (NTM) pulmonary disease in the United States. Previous studies indicate that certain trace metals in surface water increase the risk of NTM infection.

Objective: To identify whether trace metals influence the risk of NTM infection in O'ahu, Hawai'i.

Methods: A population-based ecologic cohort study was conducted using NTM infection incidence data from patients enrolled at Kaiser Permanente Hawai'i during 2005-2019. We obtained sociodemographic, microbiologic, and geocoded residential data for all Kaiser Permanente Hawai'i beneficiaries. To estimate the risk of NTM pulmonary infection from exposure to groundwater constituents, we obtained groundwater data from three data sources: (1) Water Quality Portal; (2) the Hawai'i Department of Health; and (3) Brigham Young University, Department of Geological Science faculty. Data were aggregated by an aquifer and were associated with the corresponding beneficiary aquifer of residence. We used Poisson regression models with backward elimination to generate models for NTM infection risk as a function of groundwater constituents. We modeled two outcomes: Mycobacterium avium complex (MAC) species and Mycobacterium abscessus group species.

Results: For every 1-unit increase in the log concentration of vanadium in groundwater at the aquifer level, infection risk increased by 22% among MAC patients. We did not observe significant associations between water-quality constituents and infection risk among M. abscessus patients.

Conclusions: Concentrations of vanadium in groundwater were associated with MAC pulmonary infection in O'ahu, Hawai'i. These findings provide evidence that naturally occurring trace metals influence the presence of NTM in water sources that supply municipal water systems.

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来源期刊
Environmental Epidemiology
Environmental Epidemiology Medicine-Public Health, Environmental and Occupational Health
CiteScore
5.70
自引率
2.80%
发文量
71
审稿时长
25 weeks
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