碧萝芷酚与吲哚美辛对大鼠的有益相互作用。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Bilge Ekinci, Bahadir Suleyman, Renad Mammadov, Seval Bulut, Adalet Ozcicek, Cetin Ergul, Mine Gulaboglu, Serhat Hayme, Halis Suleyman
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引用次数: 0

摘要

环氧合酶2 (COX-2)是吲哚美辛的治疗作用的原因,而抑制COX-1酶和氧化应激是其胃毒性作用的原因。有报道称碧萝芷酚增加COX-1的表达,抑制COX-2的表达率和氧化应激。本研究的目的是研究吲哚美辛、碧萝芷酚及其复方(PI)在大鼠体内的抗炎活性,并观察其对胃组织的影响。在这项研究中,研究了卡拉胶诱导的白化Wistar雄性大鼠炎性足跖水肿的抗炎活性。采用前一种方法对胃组织进行影响。PI、吲哚美辛和碧萝芷酚分别是抑制角叉菜胶炎症和氧化应激的最佳药物。爪子组织中COX-1活性最低的组分别为IC、PIC和PC,而PIC、IC和PC对COX-2活性的抑制效果最好。碧萝酚抑制胃丙二醛升高、总谷胱甘肽和COX-1降低,显著抑制吲哚美辛溃疡的形成。我们的实验结果表明,碧萝芷酚降低了吲哚美辛对胃的毒性作用,增加了抗炎活性。碧萝芷酚和吲哚美辛的这种有益的相互作用表明,PI将在治疗炎症性疾病方面取得更大的成功。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beneficial interaction of pycnogenol with indomethacin in rats.

Cyclooxygenase 2 (COX-2) is responsible for the therapeutic effects of indomethacin, while inhibition of the COX-1 enzyme and oxidative stress are responsible for its gastro-toxic effects. It has been reported that pycnogenol increases the expression of COX-1, suppresses the expression rate of COX-2 and oxidative stress. Our aim in this study is to investigate the antiinflammatory activities of indomethacin, pycnogenol, and their combination (PI) in rats and to examine their effects on stomach tissue. In the study, anti-inflammatory activity was investigated in carrageenan-induced inflammatory paw edema in albino Wistar male rats. Effects on stomach tissue were performed by applying the previous method. PI, indomethacin and pycnogenol were the best suppressors of carrageenan inflammation and oxidative stress in paw tissue, respectively. While the groups with the lowest COX-1 activity in paw tissue were IC, PIC and PC, respectively, PIC, IC and PC were the ones that best inhibited the increase in COX-2 activity. Pycnogenol inhibited the increase of malondialdehyde, the decrease of total glutathione and COX-1 in the stomach, and significantly suppressed the formation of indomethacin ulcers. Our experimental results showed that pycnogenol reduced the toxic effect of indomethacin on the stomach and increased anti-inflammatory activity. This beneficial interaction of pycnogenol and indomethacin suggests that PI will provide superior success in the treatment of inflammatory diseases.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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