三唑在有机合成中的新用途:探索其作为凝胶剂的潜力。

IF 1.7 4区 化学 Q3 CHEMISTRY, ORGANIC
Rabecca Jenifer Vasanthan, Sheersha Pradhan, Mohan Das Thangamuthu
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引用次数: 0

摘要

Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) - 通常称为 "click reaction"(点击反应) - 是在分子水平上快速构建从简单到复杂设计的最有效、最可靠的工具。它是指在各种有机反应(如环化反应、共轭加成反应、开环反应等)的帮助下,将小分子片段连接或点击在一起,从而形成碳杂原子体系。这种动态策略的结果是,在五元芳香唑环中含有三个氮原子的叠氮化物和炔烃生成了三唑及其衍生物,这些衍生物通常形成具有凝胶特性的凝胶装配结构。这些支架在设计先进的软材料、三维打印、离子传感、药物输送、光子学、分离和纯化方面有着突出的应用。在这篇综述中,我们主要强调三唑形成的不同机理,包括糖基和非糖基三唑的合成、过去十年文献中报道的凝胶应用,以及即将在不同应用科学分支中的应用范围。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging Aspects of Triazole in Organic Synthesis: Exploring its Potential as a Gelator.

Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) - commonly known as the "click reaction" - serves as the most effective and highly reliable tool for facile construction of simple to complex designs at the molecular level. It relates to the formation of carbon heteroatomic systems by joining or clicking small molecular pieces together with the help of various organic reactions such as cycloaddition, conjugate addition, ring-opening, etc. Such dynamic strategy results in the generation of triazole and its derivatives from azides and alkynes with three nitrogen atoms in the five-membered aromatic azole ring that often forms gel-assembled structures having gelating properties. These scaffolds have led to prominent applications in designing advanced soft materials, 3D printing, ion sensing, drug delivery, photonics, separation, and purification. In this review, we mainly emphasize the different mechanistic aspects of triazole formation, which includes the synthesis of sugar-based and non-sugar-based triazoles, and their gel applications reported in the literature for the past ten years, as well as the upcoming scope in different branches of applied sciences.

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来源期刊
Current organic synthesis
Current organic synthesis 化学-有机化学
CiteScore
3.40
自引率
5.60%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Current Organic Synthesis publishes in-depth reviews, original research articles and letter/short communications on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.
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