弥漫性腱鞘巨细胞瘤累及骨，伪装为朗格汉斯细胞组织细胞增生症。

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL

Case Reports in Medicine Pub Date : 2022-09-15 eCollection Date: 2022-01-01 DOI:10.1155/2022/1992541

Florence M F Cheung, Timothy Y C So, Tony H T Sung, Ying-Lee Lam

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引用次数: 1

摘要

我们报告一例弥漫性腱鞘巨细胞瘤(DTSGCT)的足伪装为朗格汉斯细胞组织细胞增多症。由于主要累及骨骼和伴随的朗格汉斯细胞的阴影效应，针活检的初步诊断是困难的。完整的刮除标本和相关的免疫组织化学和分子检测使DTSGCT的最终诊断成为可能。这种伪装现象的生物分子机制可以通过肿瘤细胞中CSF1的过表达来吸引csf1r阳性朗格汉斯细胞的迁移和增殖来解释。

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Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis.

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Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis.

We presented a case of diffuse-type tenosynovial giant cell tumour (DTSGCT) of foot masquerading as Langerhans cell histiocytosis. Preliminary diagnosis by needle biopsy was difficult due to the major involvement of bones and the overshadowing effect of the accompanying Langerhans cells. The complete curettage specimen with relevant immunohistochemistry and molecular tests made the final diagnosis of DTSGCT possible. The biomolecular mechanism for the masquerading phenomenon was explained by CSF1 overexpression in the neoplastic cells attracting migration and proliferation of CSF1R-positive Langerhans cells.

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来源期刊

Case Reports in Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

13 weeks