葡萄牙官方药典中的金鸡纳树皮和奎宁(1794-2001)。

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Pharmazie Pub Date : 2022-09-01 DOI:10.1691/ph.2022.2034

M G Semedo, A L Pereira, J R Pita

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引用次数: 0

摘要

金鸡纳树皮(金鸡纳属植物的树皮，具有抗疟疾活性)及其生物碱奎宁被广泛用于治疗间歇性发烧。本文旨在定量分析1794 - 2001年葡萄牙官方药典中金鸡纳树皮、奎宁等金鸡纳树皮衍生物质的存在。分析结果表明，Pharmacopêa葡萄牙药典(1876年)是葡萄牙官方药典中金金纳树皮含量最高的药品(2.61%)。《葡萄牙药典IV》(1935年)是官方药典，其中奎宁含量最高(2.34%)。金鸡纳树皮制成的药物在葡萄牙官方药典中一直存在，直到1946年葡萄牙药典IV (Farmacopeia portuesa IV)。自葡萄牙官方药典Codigo Pharmaceutico Lusitano(1835)以来，奎宁制成的药物已经出现在葡萄牙官方药典中。

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Cinchona bark and quinine in the Portuguese official pharmacopoeias (1794-2001).

Cinchona bark (bark from plants of the genus Cinchona with antimalarial activity) and its alkaloid quinine were widely used to treat intermittent fevers. This paper aims to quantitatively analyze the presence of Cinchona bark, quinine and other Cinchona bark-derived substances in the Portuguese official pharmacopoeias published between 1794 and 2001. The analysis showed that the Pharmacopêa Portugueza (1876) is the Portuguese official pharmacopeia with the highest percentage of medicines containing Cinchona bark (2.61%). The Farmacopeia Portuguesa IV (1935) is the official pharmacopeia with the highest percentage of quinine-containing medicines (2.34%). Medicines made from Cinchona bark are present in the Portuguese official pharmacopoeias until the Farmacopeia Portuguesa IV (1946). Medicines made from quinine have been present in Portuguese official pharmacopoeias since the Codigo Pharmaceutico Lusitano (1835).

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来源期刊

Pharmazie 医学-化学综合

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

1.2 months

期刊介绍： The journal DiePharmazie publishs reviews, experimental studies, letters to the editor, as well as book reviews. The following fields of pharmacy are covered: Pharmaceutical and medicinal chemistry; Pharmaceutical analysis and drug control; Pharmaceutical technolgy; Biopharmacy (biopharmaceutics, pharmacokinetics, biotransformation); Experimental and clinical pharmacology; Pharmaceutical biology (pharmacognosy); Clinical pharmacy; History of pharmacy.