Benralizumab治疗严重中毒性表皮坏死松解及嗜酸性粒细胞增多和全身症状重叠综合征的药物反应:1例报告

IF 0.9 Q4 DERMATOLOGY
Case Reports in Dermatology Pub Date : 2022-07-14 eCollection Date: 2022-05-01 DOI:10.1159/000525752
Felix K Zeller, Patrick R Bader, Mirjam C Nägeli, Philipp K Buehler, Reto A Schuepbach
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引用次数: 0

摘要

TEN/DRESS重叠综合征可能难以诊断,特别是在重症监护病房危重患者中被合并症掩盖的情况下。针对这两种情况的现有治疗方法也是治疗团队面临的主要挑战。一种可能的替代方案,特别是对于难治性病例,是benralizumab作为il -5受体α链特异性人源化单克隆抗体(IgG1k)。我们在这个病例报告中展示了一个成功的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report.

Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report.

Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report.

Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report.

TEN/DRESS overlap syndrome can be difficult to diagnose, especially if it is masked by comorbidities in critically ill patients in intensive care units. The existing therapy for the two conditions is also a major challenge for the treating team. A possible alternative, especially for refractory cases, is benralizumab as an IL-5-receptor alpha-chain-specific humanized monoclonal antibody (IgG1k). We are able to show a successful treatment in this case report.

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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
57
审稿时长
9 weeks
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