放射基因组学对未来前列腺癌风险分层的影响。

IF 2.6 4区 医学 Q2 UROLOGY & NEPHROLOGY
Therapeutic Advances in Urology Pub Date : 2022-09-19 eCollection Date: 2022-01-01 DOI:10.1177/17562872221125317
Vinayak Banerjee, Shu Wang, Max Drescher, Ryan Russell, M Minhaj Siddiqui
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引用次数: 3

摘要

在一个强大的计算工具的时代,放射基因组学为前列腺癌(PCa)患者的检测和诊断提供了个性化的、精确的方法。放射组学数据是通过人工智能(AI)和神经网络获得的,通过分析成像(通常是MRI)来评估图像的统计、几何和纹理特征,以提供肿瘤形状、异质性和强度的定量数据。基因组学包括评估肿瘤活检中存在的基因组标记物。在本文中,我们分别研究了PCa领域内放射组学和基因组学的现状,并使用有关该主题的三篇论文的数据讨论了两者在放射基因组学中的整合和有效性。我们还使用NIH的数据库进行了临床试验搜索,在那里我们发现了两个相关的积极招募研究。尽管需要对放射基因组学进行更多的研究,以充分采用它作为可行的诊断工具,但它通过提供每个肿瘤的个性化数据的潜力不容忽视,因为它可能是前列腺癌风险分层技术的未来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Radiogenomics influence on the future of prostate cancer risk stratification.

Radiogenomics influence on the future of prostate cancer risk stratification.

Radiogenomics influence on the future of prostate cancer risk stratification.

Radiogenomics influence on the future of prostate cancer risk stratification.

In an era of powerful computing tools, radiogenomics provides a personalized, precise approach to the detection and diagnosis in patients with prostate cancer (PCa). Radiomics data are obtained through artificial intelligence (AI) and neural networks that analyze imaging, usually MRI, to assess statistical, geometrical, and textural features of images to provide quantitative data of shape, heterogeneity, and intensity of tumors. Genomics involves assessing the genomic markers that are present from tumor biopsies. In this article, we separately investigate the current landscape of radiomics and genomics within the realm of PCa and discuss the integration and validity of both into radiogenomics using the data from three papers on the topic. We also conducted a clinical trials search using the NIH's database, where we found two relevant actively recruiting studies. Although there is more research needed to be done on radiogenomics to fully adopt it as a viable diagnosis tool, its potential by providing personalized data regarding each tumor cannot be overlooked as it may be the future of PCa risk-stratification techniques.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
39
审稿时长
10 weeks
期刊介绍: Therapeutic Advances in Urology delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of urology. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in urology, providing a forum in print and online for publishing the highest quality articles in this area. The editors welcome articles of current interest across all areas of urology, including treatment of urological disorders, with a focus on emerging pharmacological therapies.
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