儿童胃肠病学门诊慢性疾病患儿SARS-CoV-2抗体

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2022-09-01 Epub Date: 2022-09-05 DOI:10.5223/pghn.2022.25.5.422
Gulay Kaya, Fatma Issi, Burcu Guven, Esra Ozkaya, Celal Kurtulus Buruk, Murat Cakir
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引用次数: 1

摘要

目的:在新型冠状病毒病(COVID-19)流行初期,医生密切关注儿童慢性疾病,以防止传播或严重感染。目的检测慢性胃肠道和肝脏疾病患儿的严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)抗体水平,分析其感染的危险因素及其与原发病的相互作用。方法:本横断面研究分析了2021年1月至2月期间胃肠道和肝脏疾病患者(n=141)和健康儿童(n=48)的SARS-CoV-2抗体水平。结果:大流行期间,10例患者(7%)和1例儿童(2%)确诊感染COVID-19 (p=0.2)。SARS-CoV-2抗体检测阳性患者36例(25.5%),儿童11例(22.9%)(p=0.7)。慢性肝病、慢性胃肠道疾病、囊性纤维化和肝移植患者中SARS-CoV-2抗体阳性率分别为20.4%、26.6%、33.3%和33.3%(患者与健康儿童比较,p>0.05)。SARS-CoV-2抗体阳性的危险因素为与covid -19相关的症状(47.2%比14.2%,p=0.00004)和与SARS-CoV-2聚合酶链反应阳性患者密切接触(69.4%比9%,pp=0.35)。结论:慢性胃肠和肝脏疾病患儿的SARS-CoV-2抗体与健康儿童相似。密切随访对于了解这些儿童过去感染COVID-19的长期影响非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

SARS-CoV-2 Antibodies in Children with Chronic Disease from a Pediatric Gastroenterology Outpatient Clinic.

SARS-CoV-2 Antibodies in Children with Chronic Disease from a Pediatric Gastroenterology Outpatient Clinic.

SARS-CoV-2 Antibodies in Children with Chronic Disease from a Pediatric Gastroenterology Outpatient Clinic.

SARS-CoV-2 Antibodies in Children with Chronic Disease from a Pediatric Gastroenterology Outpatient Clinic.

Purpose: At the beginning of the Coronavirus disease (COVID-19) epidemic, physicians paid close attention to children with chronic diseases to prevent transmission or a severe course of infection. We aimed to measure the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels in children with chronic gastrointestinal and liver diseases to analyze the risk factors for infection and its interaction with their primary disease.

Methods: This cross-sectional study analyzed SARS-CoV-2 antibody levels in patients with gastrointestinal and liver diseases (n=141) and in healthy children (n=48) between January and February 2021.

Results: During the pandemic, 10 patients (7%) and 1 child (2%) had confirmed COVID-19 infection (p=0.2). The SARS-CoV-2 antibody test was positive in 36 patients (25.5%) and 11 children (22.9%) (p=0.7). SARS-CoV-2 antibody positivity was found in 20.4%, 26.6%, 33.3%, and 33.3% of patients with chronic liver diseases, chronic gastrointestinal tract diseases, cystic fibrosis, and liver transplantation recipients, respectively (p>0.05, patients vs. healthy children). Risk factors for SARS-CoV-2 antibody positivity were COVID-19-related symptoms (47.2% vs. 14.2%, p=0.00004) and close contact with SARS-CoV-2 polymerase chain reaction-positive patients (69.4% vs. 9%, p<0.00001). The use, number, and type of immunosuppressants and primary diagnosis were not associated with SARS-CoV-2 antibody positivity. The frequency of disease activation/flare was not significant in patients with (8.3%) or without (14.2%) antibody positivity (p=0.35).

Conclusion: SARS-CoV-2 antibodies in children with chronic gastrointestinal and liver diseases are similar to that in healthy children. Close follow-up is important to understand the long-term effects of past COVID-19 infection in these children.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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