感染性发热及其与il - 6 rs1800796多态性的相互作用对乳腺癌预后的影响

IF 3.4
Hengming Ye, Lu-Ying Tang, Zhuo-Zhi Liang, Qian-Xin Chen, Yun-Qian Li, Qiang Liu, Xiaoming Xie, Ying Lin, Ze-Fang Ren
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引用次数: 1

摘要

背景:既往研究发现,急性发热性感染可降低乳腺癌发病风险。同时,众所周知,白细胞介素-6 (interleukin-6, IL6)在肿瘤微环境中起着双重作用。发热可能刺激IL6的产生,IL6 rs1800796也影响IL6的表达。然而,发热及其与IL6 rs1800796的相互作用对乳腺癌生存的影响仍有待探讨。方法:这是一项包含4223名乳腺癌患者的前瞻性队列研究。暴露为诊断前/诊断后感染诱发发热和rs1800796多态性。终点是总生存期(OS)和无进展生存期(PFS)。校正后的风险比采用多变量Cox比例风险回归模型。结果:与未诊断前发热的妇女相比,诊断前发热的妇女进展的调整危险比(HR)为0.81 (95% CI, 0.66-0.99),特别是CC基因型IL6 rs1800796 (HR, 0.53;95% ci, 0.36-0.79)。OS也较好(HR, 0.59;在CC基因型暴露于诊断前发热的女性中,95% CI, 0.36-0.99),伴有显著的相互作用(P = 0.021)。诊断后发热可改善乳腺癌的PFS (HR, 0.72;95% ci, 0.52-1.00)。无论il - 6基因型如何,淋巴结阳性妇女诊断后发热(HR, 0.57;95% CI, 0.37-0.89)的进展风险低于淋巴结阴性女性(HR, 1.12;95% ci, 0.70-1.79)。结论:感染引起的发热有利于乳腺癌的生存,特别是对于CC基因型为IL6 rs1800796或淋巴结阳性的女性。影响:本研究为感染引起的发热作为乳腺癌潜在预后标志物和治疗方案的作用提供了新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Infection-Induced Fever and the Interaction with IL6 rs1800796 Polymorphism on the Prognosis of Breast Cancer.

Background: Previous studies have found that acute febrile infection may decrease the risk of breast cancer. Meanwhile, it is well known that interleukin-6 (IL6) played dual roles in the tumor microenvironment. Fever may stimulate IL6 production, and IL6 rs1800796 also influences the expression of IL6. However, the impact of fever and its interaction with IL6 rs1800796 on breast cancer survival remains to be explored.

Methods: This was a prospective cohort study of 4,223 breast cancer patients. Exposures were pre-/postdiagnostic infection-induced fever and rs1800796 polymorphism. The endpoints were overall survival (OS) and progression-free survival (PFS). Adjusted hazard ratios were obtained using multivariate Cox proportional hazards regression models.

Results: Compared with women without prediagnostic fever, the adjusted hazard ratio (HR) of progression for those with prediagnostic fever was 0.81 (95% CI, 0.66-0.99), particularly for the CC genotype of IL6 rs1800796 (HR, 0.53; 95% CI, 0.36-0.79). OS was also better (HR, 0.59; 95% CI, 0.36-0.99) among women with the CC genotype exposed to prediagnostic fever, accompanied by a significant interaction (P = 0.021). Postdiagnostic fever conferred better PFS for breast cancer (HR, 0.72; 95% CI, 0.52-1.00). Irrespective of the genotype of IL6, lymph node-positive women with postdiagnostic fever (HR, 0.57; 95% CI, 0.37-0.89) had a lower risk of progression than lymph node-negative women (HR, 1.12; 95% CI, 0.70-1.79).

Conclusions: Infection-induced fever was beneficial to breast cancer survival, particularly for women who were the CC genotype of IL6 rs1800796 or node positive.

Impact: This study provides new insight into the roles of infection-induced fever as a potential prognostic marker and therapy regimen for breast cancer.

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