阿奇霉素给药及提高生物利用度策略研究进展。

IF 1.6 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Assay and drug development technologies Pub Date : 2022-08-01 Epub Date: 2022-09-08 DOI:10.1089/adt.2022.036

Pallavi Swarup, Gopal Prasad Agrawal

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引用次数: 1

摘要

阿奇霉素(AZI)属于水溶性有限的大环内酯类抗生素，属于生物制药分类系统第二类。溶解是AZI吸附过程中的限速步骤。研究了几种提高难溶性药物生物利用度的方法。本综述旨在探讨已研究的改善AZI溶解度和/或生物利用度的各种策略，以及设计用于在眼液中递送AZI的递送系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Review on Delivery and Bioavailability Enhancement Strategies of Azithromycin.

Azithromycin (AZI) belongs to the class of macrolide antibiotics that has limited water solubility and belongs to Biopharmaceutical Classification System Class II. Dissolution is the rate-limiting step in the absorption process of AZI. Several approaches have been investigated for enhancing the bioavailability of poorly soluble drugs. This review intends to explore the various strategies that have been investigated for improving the solubility and/or bioavailability of AZI and the delivery systems that have been designed for delivery of AZI in ocular fluid.

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来源期刊

Assay and drug development technologies 医学-生化研究方法

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts