印度尼西亚国家转诊传染病医院住院肺炎患者抗菌药物敏感性分析

Advances in Medicine Pub Date : 2022-08-29 eCollection Date: 2022-01-01 DOI:10.1155/2022/3455948
Pompini Agustina Sitompul, Roza Indriani, Adria Rusli, Titi Sundari, Rosamarlina Rosamarlina, Teguh Sarry Hartono, Siti Maemun, Mohammad Syahril, Diar Riyanti Rudiatmoko, Vivi Setiawaty
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引用次数: 0

摘要

背景:肺炎仍然是一个具有高发病率和高死亡率的主要全球性问题。细菌,特别是耐多药病原体引起的肺炎病例数量的增加,人口年龄的增加,慢性病患者(合并症)以及初始给药时不适当的抗菌药物治疗使治疗变得不那么有效。这些问题最终导致住院肺炎患者较高的发病率和死亡率。因此,了解微生物模式并根据局部抗菌药物敏感性模式选择治疗方法至关重要。方法:对印度尼西亚国家转诊传染病医院2015年1月至2016年12月住院的肺炎患者进行横断面研究。从医疗记录中收集数据,以显示患者特征、抗菌治疗数据、培养检查和细菌敏感性。结果:99例肺炎患者住院并行痰培养检查。患者以65岁以上(32.3%)和男性(57.6%)居多。最常见的合并症是肺结核(21%),其他合并症是心力衰竭、慢性阻塞性肺病(COPD)和艾滋病毒/艾滋病。痰培养检出真菌(56%)最多,检出的细菌为肺炎克雷伯菌(14%)、不动杆菌(12%)和假单胞菌(8%)。第三代头孢菌素,如头孢曲松(50%),通常用作治疗肺炎的抗生素。结论:痰培养中最常见的细菌为肺炎克雷伯菌,对-内酰胺类和氨基糖苷类更为敏感。较高的危险因素是65岁以上、男性和患有肺结核。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antimicrobial Sensitivity Pattern from Hospitalized Pneumonia Patients in National Referral Infectious Disease Hospital in Indonesia.

Background: Pneumonia is still a major global problem with high morbidity and mortality. The increasing number of pneumonia cases caused by bacteria, especially multidrug-resistant pathogens, increasing age of the population, patients with chronic disease (comorbid), and inappropriate antimicrobial therapy at initial administration make the treatment become less effective. These issues finally contribute to higher morbidity and mortality in cases of hospitalized pneumonia patients. Therefore, it is crucial to know the microbial pattern and select the therapy according to local antimicrobial sensitivity patterns.

Method: A cross-sectional study was conducted for hospitalized pneumonia patients between January 2015 and December 2016 in Indonesia National Referral Infectious Disease Hospital. Data were collected from medical records to show patient characteristics, antimicrobial treatment data, culture examination, and bacterial sensitivity.

Results: A total of 99 pneumonia patients required hospitalization and underwent sputum culture examination. The patients were mostly above 65 years old (32.3%) and male (57.6%). The most common comorbidities were pulmonary tuberculosis (21%), and the others were heart failure, chronic obstructive pulmonary disease (COPD), and HIV/AIDS. Based on the sputum culture, fungi were identified in most specimens (56%), while the bacteria identified were Klebsiella pneumoniae (14%), Acinetobacter sp. (12%), and Pseudomonas sp. (8%). Third-generation cephalosporin, such as ceftriaxone (50%), was commonly used as an antibiotic for pneumonia treatment.

Conclusion: Most common bacteria isolated from sputum culture were Klebsiella pneumoniae which were more sensitive to the beta-lactam and aminoglycoside groups. The higher risk factors were age above 65 years old, being male, and having tuberculosis.

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