G蛋白偶联受体mas相关基因X2 (MrgX2)的起源、表达、功能及未来研究重点

Q Medicine
Haihui Wu , Meiqi Zeng , Eric Y.P Cho , Wenqi Jiang , Ou Sha
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引用次数: 16

摘要

mas相关基因(Mrgs)属于在啮齿类动物中发现的G蛋白偶联受体基因大家族。人MRGX蛋白是G蛋白偶联的7-跨膜蛋白,彼此具有41-52%的氨基酸同源性,但在啮齿动物中没有同源物。MrgX2是MrgX家族的成员。MRGX2在感觉神经节和肥大细胞的小神经元中表达。它可以与肽物质P、血管活性肠肽、皮质抑素(CST)、肾上腺髓质素前n端肽(PAMP)、LL-37、PMX-53、β-防御素等一系列因子和基因相互作用。MRGX2与痛觉、肾上腺分泌和肥大细胞脱颗粒有关。最近对MrgX2的研究提供了对其在伤害感受和抗微生物活性中的作用的见解。本文综述了MrgX2的来源、表达和功能,并对未来可能的研究重点进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Origin, Expression, Function and Future Research Focus of a G Protein-coupled Receptor, Mas-related Gene X2 (MrgX2)

Mas-related genes (Mrgs) belong to a large family of G protein-coupled receptor genes found in rodents. Human MRGX proteins are G protein-coupled 7-transmembrane proteins sharing 41-52% amino acid identity with each other, but have no orthologs in rodents. MrgX2 is a member of the MrgX family. MRGX2 is expressed in the small neurons of sensory ganglia and mast cells. It can interact with a series of factors and genes such as the peptides substance P, vasoactive intestinal peptide, cortistatin (CST), proadrenomedullin N-terminal peptide (PAMP), LL-37, PMX-53 and β-defensins. MRGX2 is related to nociception, adrenal gland secretion and mast cell degranulation. Recent research on MrgX2 provides insights into its role in nociception and anti-microbial activities. This article reviewed the origin, expression and function of MrgX2, and discussed possible future research focus.

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来源期刊
CiteScore
4.67
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Histochemistry and Cytochemistry publishes comprehensive and analytical reviews within the entire field of histochemistry and cytochemistry. Methodological contributions as well as papers in the fields of applied histo- and cytochemistry (e.g. cell biology, pathology, clinical disciplines) will be accepted.
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