人类表皮抗菌屏障:当前的知识,临床相关性和治疗意义。

Q3 Medicine
Roshan Gunathilake
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引用次数: 3

摘要

人类皮肤的大部分防御功能都定位于角质层(SC),角质层是表皮的最外层,由嵌入在脂质基质中的几层角质形成细胞组成。表皮屏障包括表面pH值、SC脂质、特殊抗菌肽(如防御素和抗菌肽)、酶和酶抑制剂、趋化因子和表皮toll样受体。多种表皮防御机制是共定位、共调节和相互交织的。本综述的目的是讨论专利,并描述当前关于表皮作为抗菌屏障作用的知识,概述潜在的临床和治疗意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Human Epidermal Antimicrobial Barrier: Current Knowledge, Clinical Relevance and Therapeutic Implications.

Most of the defensive functions of the human skin are localized to the stratum corneum (SC), the outermost layer of the epidermis consisting of several layers of cornified keratinocytes embedded in a lipid matrix. Included in the armamentarium of the epidermal barrier against microbial invasion are surface pH, SC lipids, specialized antimicrobial peptides such as defensins and cathelicidins, enzymes and enzyme inhibitors, chemokines, and epidermal Toll-like receptors. Multiple epidermal defensive mechanisms are co-localized, coregulated, and intertwined. The purpose of this review is to discuss patents and to describe the current knowledge that concerns the role of the epidermis as an antimicrobial barrier, outlining potential clinical and therapeutic implications.

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来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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