转录因子在胃粘膜转分化中的作用。

TSitologiia i genetika Pub Date : 2015-03-01

S V Vernygorodskyi, L V Degtiariova, O I Iatsyna, Ya B Blume, A I Yemets

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引用次数: 0

摘要

在胃粘膜活检中对肠分化转录因子CDX2进行了分析。证实CDX2通过自身启动子激活途径可获得胃粘膜细胞肠道表型。化生上皮细胞核中CDX2表达的缺失可能是胃粘膜恶性化的一个预测因子。

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[Role of transcription factors in transdifferentiation of the gastric mucosa].

The analysis of intestinal differentiation transcription factor CDX2 in the gastric mucosa biopsies has been carried out. It was established that CDX2 by itself promoter activation pathway can obtain intestinal phenotype for gastric mucosa cells. The loss of CDX2 expression in the nuclei of metaplastic epithelium may serve as a predictor of gastric mucosa malignization.

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TSitologiia i genetika

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