Foxp3-3279 (rs376158)多态性与尘螨变应性结膜炎的关系

眼科学报 Pub Date : 2014-09-01

Ruiming Yang, He Lai, Xiangyin Sha, Shengqiang Chen, Yingqian Tan, Weifang Chen, Zhiping Liu

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引用次数: 0

摘要

目的:对广东地区尘螨致变应性结膜炎患者Foxp3-3279 (A/Crs376158)基因进行分型分析，探讨该基因与尘螨致变应性结膜炎易感性的关系。方法:选取80例尘螨变应性结膜炎患者和103例健康汉族患者，采用PCR-SSP技术进行Foxp3-3279 (A/C,rs376158)基因分型。结果:尘螨变应性结膜炎患者Foxp3-3279 AA、CA和CC基因型频率分别为1.25%、25.00%和73.75%。尘螨变应性结膜炎患者C、A基因频率分别为86.25%、13.75%，与健康对照组比较差异无统计学意义(P > 0.05)。结论:Foxp3-3279基因多态性在尘螨变应性结膜炎患者与健康对照组间无显著差异，提示该基因位点可能不是尘螨变应性结膜炎发病机制的独立危险因素。

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Relationship between Foxp3-3279 (rs376158) polymorphism and dust mite allergic conjunctivitis.

Purpose: To investigate the genotyping of Foxp3-3279 (A/Crs376158) genes in patients with dust mite-induced allergic conjunctivitis from Guangdong province and to explore the association between these genes and the susceptibility to dust mite allergic conjunctivitis.

Methods: In total, 80 patients with dust mite allergic conjunctivitis and 103 healthy Han Chinese were enrolled in the study and received genotyping of Foxp3-3279 (A/C,rs376158) by PCR-SSP technique.

Results: Genotype frequency of Foxp3-3279 AA, CA, and CC in patients with dust mite allergic conjunctivitis were 1.25%, 25.00% and 73.75%,respectively. Gene frequency of C and A in patients with dust mite allergic conjunctivitis were 86.25% and 13.75% with no significant difference from healthy counterparts (both P > 0.05).

Conclusion: Foxp3-3279 polymorphisms did not significantly differ between patients with dust mite allergic conjunctivitis and healthy controls, implying that this genetic locus is probably not an independent risk factor of the underlying pathogenesis of dust mite allergic conjunctivitis.

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来源期刊

眼科学报

自引率

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发文量

1312

期刊介绍： Eye science was founded in 1985. It is a national medical journal supervised by the Ministry of Education of the People's Republic of China, sponsored by Sun Yat-sen University, and hosted by Sun Yat-sen University Zhongshan Eye Center (in October 2020, it was changed from a quarterly to a monthly, with the publication number: ISSN: 1000-4432; CN: 44-1119/R). It is edited by Ge Jian, former dean of Sun Yat-sen University Zhongshan Eye Center, Liu Yizhi, director and dean of Sun Yat-sen University Zhongshan Eye Center, and Lin Haotian, deputy director of Sun Yat-sen University Zhongshan Eye Center, as executive editor. It mainly reports on new developments and trends in the field of ophthalmology at home and abroad, focusing on basic research in ophthalmology, clinical experience, and theoretical knowledge and technical operations related to epidemiology. It has been included in important databases at home and abroad, such as Chemical Abstract (CA), China Journal Full-text Database (CNKI), China Core Journals (Selection) Database (Wanfang), and Chinese Science and Technology Journal Database (VIP).