N V Kostiuk, M B Belyakova, D V Leshchenko, V V Zhigulina, M V Miniaev
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Synthetic melatoninergic ligands: achievements and prospects.
Pineal hormone melatonin is widely used in the treatment of disorders of circadian rhythms. The presence of melatonin receptors in various animal tissues motivates the use of this hormone in some other diseases. For this reason, in recent years investigators continued the search for synthetic analogues of melatonin which are metabolically stable and selective to receptors. This review includes recent information about the most famous melatonin analogues, their structure, properties, and physiological features of the interaction with melatonin receptors.
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