应用醋酸铅后大鼠牙齿的免疫组织化学和组织病理学变化。

IF 0.1 4区 医学 Q4 Medicine
Faruk Er, Mahmut Koparal, Engin Deveci, Sevgi Irtegün
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引用次数: 0

摘要

目的:通过观察铅对大鼠门牙的组织病理学和免疫组化作用,探讨铅在牙中的毒性作用过程。研究设计:Wistar Albino大鼠30只,体重180 ~ 200 g,分为2组:对照组和醋酸铅组(即实验组)。实验组饮用500ppm醋酸铅60天,对照组饮用蒸馏水。对照组与试验组切片进行组织病理学比较。结果:分析了下颌切牙的纵切面。牙周膜变性,牙髓血管扩张,炎症细胞浸润,牙髓和牙周膜可见vimentin表达。结论:牙本质小管中有波形蛋白的存在,表明这些小管的成牙突呈阳性。实验组牙本质小管轮廓受损,排列紊乱。结果表明,实验组门牙牙周膜胶原纤维明显减少。在同一组中,由于位于牙槽骨和牙周韧带之间的中间丝的间距,门牙的咬合功能受到影响。醋酸铅处理降低了牙组织中vimentin的表达。醋酸铅会影响牙齿与牙槽骨的粘连。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunohistochemical and histopathological changes in the teeth of rats after lead acetate application.

Objective: To study the toxic processes of lead in teeth by investigating the histopathologic and immunohistochemical effects of lead on incisor teeth of rats.

Study design: Thirty Wistar Albino rats weighing 180-200 g were divided into 2 groups: a control group and a lead acetate group (i.e., the experimental group). The experimental group received lead acetate at 500 ppm in their drinking water for 60 days, and the control group received distilled water. The sections of the control group and the experiment group were histopathologically compared.

Results: The longitudinal cross-sections of the mandibular incisor teeth were analyzed. Degeneration in the periodontal membrane and vascular dilation in pulp and inflammatory cell infiltration were observed, and vimentin expression was seen in the dental pulp and the periodontal membrane.

Conclusion: The presence of vimentin in the dentinal tubules indicated that the odontoblast processes in these tubules were positive. In the experimental group the profile of dentinal tubules was found to be impaired and disorganized. These results indicate a loss of collagen fibers in the periodontal membrane of incisor teeth in the experimental group. In the same group the gripping function of the incisor teeth was affected due to the spacing of the intermediate filaments that are located between the alveolar bone and the periodontal ligament. The expression of vimentin on the tooth was reduced by the lead acetate treatment. Lead acetate may affect the adhesion of the tooth to the alveolar bone.

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审稿时长
1 months
期刊介绍: AQCH is an Official Periodical of The International Academy of Cytology and the Italian Society of Urologic Pathology.
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