一个n=1的病例报告,一个患有自闭症的孩子服用抗生素后病情有所好转,一位父亲试图了解这可能意味着什么。

Microbial Ecology in Health and Disease Pub Date : 2015-03-24 eCollection Date: 2015-01-01 DOI:10.3402/mehd.v26.26382
John Rodakis
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引用次数: 17

摘要

提交人是一名自闭症儿童的父母,他描述了一个n=1的案例,在使用一种普通抗生素后,他孩子的自闭症症状显著而迅速地改善。作者断言,这一发现在自闭症人群中并不罕见,而且,当与之前最近的医学研究相结合时,表明自闭症与某些儿童的微生物群之间的联系不仅是似是而非的,而且实际上可能在一定比例的病例中存在。作者主张增加资金,对自闭症和微生物群之间的联系进行更彻底的研究,并提出了一系列问题,以便在未来的研究中进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An n=1 case report of a child with autism improving on antibiotics and a father's quest to understand what it may mean.

An n=1 case report of a child with autism improving on antibiotics and a father's quest to understand what it may mean.

The author, a parent of a child with autism, describes an n=1 case in which his child's autism symptoms dramatically and rapidly improved following administration of a common antibiotic. The author asserts that this finding is not unusual in the autism population and that, when combined with prior recent medical research, suggests that a link between autism and the microbiome in some children is not just plausible, but in fact likely for some meaningful percentage of cases. The author argues for increased funding for a more thorough examination of links between autism and the microbiome and poses a series of questions to be further examined in future research.

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