Ca(2+)-信号传导机制的进化。Ca2+在慢性心脏病心肌细胞特化功能调控中的作用[j]。

Zhurnal evoliutsionnoi biokhimii i fiziologii Pub Date : 2014-11-01

I V Shemarova, V P Nesterov

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引用次数: 0

摘要

这篇综述考虑了Ca2+离子在心脏活动紊乱中对心肌细胞(CM)特殊功能的调节作用。Ca(2+)依赖性信号机制导致病理性肥厚、心律失常和心力衰竭的问题被阐明。特别注意的是分析Ca(2+)依赖的分子机制，导致收缩蛋白重塑、细胞凋亡或CM的病理生长。

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[Evolution of mechanisms of Ca(2+)-signaling. Role of Ca2+ in regulation of specialized functions of cardiomyocytes in chronic heart diseases].

The review considers role of Ca2+ ions in regulation of specialized functions of cardiomyocytes (CM) in disturbances of heart activity. Problems of Ca(2+)-dependent signaling mechanisms leading to pathological hypertrophy, arrythmogenesis, and heart failure are elucidated. A particular attention is paid to analysis of Ca(2+)-dependent molecular mechanisms leading to remodeling of contractile proteins, apoptosis, or pathological growth of CM.

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Zhurnal evoliutsionnoi biokhimii i fiziologii

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