2012 年朝觐期间全身使用皮质类固醇治疗呼吸道感染的疗效。

IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2015-01-07 eCollection Date: 2015-01-01 DOI:10.5812/ircmj.12859
Aminreza Tabatabaei, Abbas Heidarzadeh, Navvab Shamspour, Pirhosein Kolivand
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引用次数: 0

摘要

背景:在朝觐等人群聚集的情况下诊断和治疗呼吸道感染 (RTI) 是一项医学挑战,需要快速做出决策,并掌握大量有关病因和治疗方法的知识。朝觐期间 RTI 的高发病率和大篷车医生在这种情况下迅速治疗病人的倾向导致了肠外类固醇的处方。然而,目前还没有研究重点关注全身性类固醇对患有 RTI 的朝觐者的短期和长期影响:本研究重点关注全身使用皮质类固醇对缓解 RTI 症状的疗效:这项临床试验纳入了2012年朝觐中的1671名朝觐者,这些朝觐者根据大篷车医生的检查结果出现了RTI症状。患者被分为两组,分别接受肠外皮质类固醇或其他药物治疗。因细菌感染而接受抗生素治疗的患者被排除在外。本次调查的重点是朝觐期间 RTI 的一般症状,如服药前、服药 24 小时后和服药 5 天后的发热、肌肉骨骼疼痛、喉咙痛、咳嗽、呼吸困难和声音嘶哑。使用 SPSS 17 对数据进行分类和分析。比较变量时使用了描述性统计和卡方检验:结果:与注射皮质类固醇相比,不注射皮质类固醇的治疗在五天内退热效果更明显(P < 0.05),而在 48 小时后则没有效果(P > 0.05)。虽然皮质类固醇在最初 48 小时内可减轻症状(P > 0.05),但在使用五天后就没有效果了(P > 0.05)。使用皮质类固醇以外的药物治疗对减少流涎的效果较差(P > 0.05),而皮质类固醇对流涎、咳嗽和肌肉骨骼疼痛有明显缓解作用(P < 0.05):有必要对皮质类固醇和抗生素联合疗法的效果及其对免疫系统的短期和长期不良影响进行更全面的研究。虽然注射皮质类固醇是 RTI 患者的常用疗法,但由于缺乏有关其长期治疗效果和不良反应的数据,因此不建议使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The efficacy of systemic corticosteroids in treatment of respiratory tract infections during hajj 2012.

Background: Diagnosis and treatment of respiratory tract infections (RTI) in a mass-gathering situation such as hajj is a medical challenge that requires quick decision-making and considerable knowledge about its etiology and treatment methods. High prevalence of RTI during Hajj and tendency of caravan physicians to treat of patients quickly in such situation lead to prescription of parenteral steroids. Nonetheless, no study has focused on the short-term and long-term effects of systemic steroids in Hajj pilgrims with RTI.

Objectives: This study focuses on efficacy of systemic consumption of corticosteroids in alleviating symptoms of RTI.

Patients and methods: This clinical trial was included 1671 pilgrims in Hajj 2012 who had symptoms of RTI based on caravan physician's findings. The patients were divided to two groups to receive either parenteral corticosteroid or other drugs. Patients who received antibiotics for bacterial infections were excluded. This survey concentrated on general symptoms of RTI during Hajj such as fever, musculoskeletal pain, coryza, sore throat, cough, dyspnea, and hoarseness before, 24 hours after, and five days after drug consumption. For classification and analysis of data, SPSS 17 was used. Descriptive statistical and Chi square test were used to compare variables.

Results: In comparison to corticosteroid injection, treatment without systemic corticosteroids could reduce the fever more significantly within five days (P < 0.05), while it had no effect after 48 hours (P > 0.05). Although corticosteroids alleviated the symptoms during the first 48 hours (P > 0.05), they had no more effect after five days of consumption (P > 0.05). Treatment with medications other than corticosteroid had less effect on reducing coryza (P > 0.05) while corticosteroids had significant alleviating effect on coryza, cough, and musculoskeletal pain (P < 0.05).

Conclusions: There is a need to conduct more comprehensive studies on effect of combination therapy with corticosteroids and antibiotics as well as their short-term and long-term adverse effects on the immune system. While injecting corticosteroids is commonly administered in patients with RTI, they are not recommended due to the lack of data on their long-term therapeutic and adverse effects.

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来源期刊
Iranian Red Crescent Medical Journal
Iranian Red Crescent Medical Journal 医学-医学:内科
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期刊介绍: The IRANIAN RED CRESCENT MEDICAL JOURNAL is an international, English language, peer-reviewed journal dealing with general Medicine and Surgery, Disaster Medicine and Health Policy. It is an official Journal of the Iranian Hospital Dubai and is published monthly. The Iranian Red Crescent Medical Journal aims at publishing the high quality materials, both clinical and scientific, on all aspects of Medicine and Surgery
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