二十碳五烯酸与二十二碳六烯酸对幽门螺杆菌血清脂蛋白水平影响的比较:一项随机临床试验

IF 0.4 4区 医学
Iranian Red Crescent Medical Journal Pub Date : 2014-12-22 eCollection Date: 2015-01-01 DOI:10.5812/ircmj.17652
Shahram Agah, Farzad Shidfar, Nafiseh Khandouzi, Ahmad Reza Baghestani, Sharieh Hosseini
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引用次数: 5

摘要

背景:幽门螺杆菌感染是世界范围内最常见的慢性细菌性感染,是引起胃肠道疾病的重要原因之一,可能与一些胃肠外紊乱的发病机制及血脂变化有关。omega-3脂肪酸的低血脂特性已经在几项研究中得到了研究。目的:本研究旨在比较补充二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)对幽门螺杆菌血清脂蛋白水平的影响。患者和方法:在伊朗进行的一项随机、双盲、安慰剂对照临床试验中,105名幽门螺杆菌被随机分配到每天接受2g EPA(35名患者)、DHA(35名患者)或中链甘油三酯(MCT)油作为安慰剂(33名患者),同时接受传统的四药幽门螺杆菌根除方案,持续12周。结果:在105例纳入的患者中,97例(EPA组31例,DHA组33例,对照组33例)完成了研究并纳入最终分析。三组患者总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平及TG/HDL-C、TC/HDL-C、LDL-C/HDL-C比值差异无统计学意义,甘油三酯(TG)水平差异有统计学意义。DHA组(-16.6±30.34)与对照组(+ 15.32±56.47)TG水平变化差异有统计学意义(P = 0.000)。结论:连续12周补充2g EPA或DHA对总胆固醇、LDL-C、HDL-C、TC/HDL-C、TG/HDL-C和LDL-C/HDL-C水平的影响无差异;然而,在某种程度上,它对TG水平的影响比DHA的影响更明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Comparison of the Effects of Eicosapentaenoic Acid With Docosahexaenoic Acid on the Level of Serum Lipoproteins in Helicobacter pylori: A Randomized Clinical Trial.

Comparison of the Effects of Eicosapentaenoic Acid With Docosahexaenoic Acid on the Level of Serum Lipoproteins in Helicobacter pylori: A Randomized Clinical Trial.

Background: Helicobacter pylori infection is the most common chronic bacterial infection around the world and an important cause of gastrointestinal disorders, which might be involved in the pathogenesis of some extragastrointestinal disturbances as well as changes in serum lipid profile. Hypolipemic properties of omega-3 fatty acids have been studied in several studies.

Objectives: The present study aimed to compare the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on the level of serum lipoproteins in H. pylori.

Patients and methods: In a randomized, double-blinded, placebo-controlled clinical trial in Iran, 105 Helicobacter pylori were randomly allocated to receive 2 g of daily EPA (35 patients), DHA (35 patients), or medium-chain triglyceride (MCT) oil as placebo (33 patients) along with conventional tetra-drug H. pylori eradication regimen for 12 weeks.

Results: From 105 included patients, 97 (31 in EPA, 33 in DHA, and 33 in control groups) completed the study and were included in final analysis. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and the ratios of TG/HDL-C, TC/HDL-C, and LDL-C/HDL-C were not significantly different among the three groups, while the level of triglyceride (TG) was statistically different. DHA (-16.6 ± 30.34) and control (+ 15.32 ± 56.47) groups were statistically different with regard to changes in TG levels (P = 0.000).

Conclusions: There was no difference between the effects of 2 g of EPA or DHA supplementation for 12 weeks on the levels of total cholesterol, LDL-C, HDL-C, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C; however, it had a desirable effect on the level of TG in a way that the effect of DHA was clearer.

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来源期刊
Iranian Red Crescent Medical Journal
Iranian Red Crescent Medical Journal 医学-医学:内科
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期刊介绍: The IRANIAN RED CRESCENT MEDICAL JOURNAL is an international, English language, peer-reviewed journal dealing with general Medicine and Surgery, Disaster Medicine and Health Policy. It is an official Journal of the Iranian Hospital Dubai and is published monthly. The Iranian Red Crescent Medical Journal aims at publishing the high quality materials, both clinical and scientific, on all aspects of Medicine and Surgery
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