精神分裂症患者未被识别的心肌梗死。

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Acta Neuropsychiatrica Pub Date : 2015-04-01 Epub Date: 2015-01-13 DOI:10.1017/neu.2014.41
Jimmi Nielsen, Jacob Juel, Karam Sadoon Alzuhairi, Karam Sadoon Majeed Al Zuhairi, Rasmus Friis, Claus Graff, Jørgen Kim Kanters, Svend Eggert Jensen
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引用次数: 36

摘要

目的:精神分裂症与寿命减少20年相关,II型糖尿病和心血管疾病对死亡率增加的贡献最大。未被识别或无症状的心肌梗死(MI)发生在约30%的人群中,但未被识别的心肌梗死在精神分裂症患者中的发生率仅被很少调查。方法:对来自丹麦三家精神病院的心电图(ECG)进行人工解读,以寻找既往心肌梗死的迹象。随后,将心电图与国家患者登记处联系起来,以确定患者的诊断是否与既往心肌梗死一致。结果:共解读了937张心电图,其中538名男性(57.4%)和399名女性(42.6%)。获得心电图时的平均年龄为40.6岁(95% CI: 39.7-41.5,范围:15.9-94.6)。我们确定了32例有心肌梗死阳性心电图征象的患者。这些患者中只有两名在国家患者登记处被诊断为心肌梗死。另有8名患者在丹麦国家患者登记处被诊断为心肌梗死,但之前没有心肌梗死的心电图征象。这意味着40例心肌梗死中有30例(75%)未被识别。在逐步多元logistic回归模型中,与无心肌梗死病史的患者相比,只有年龄增加与未识别的心肌梗死相关,OR: 1.03 /年,95% CI: 1.00-1.06, p=0.021。结论:未被识别的心肌梗死在精神分裂症患者中很常见,并可能导致该患者组死亡率增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unrecognised myocardial infarction in patients with schizophrenia.

Objective: Schizophrenia is associated with a reduction of the lifespan by 20 years, with type II diabetes and cardiovascular disease contributing the most to the increased mortality. Unrecognised or silent myocardial infarction (MI) occurs in ~30% of the population, but the rates of unrecognised MI in patients with schizophrenia have only been sparsely investigated.

Method: Electrocardiograms (ECG) from three psychiatric hospitals in Denmark were manually interpreted for signs of previous MI. Subsequently, ECGs were linked to the National Patient Registry in order to determine whether patients had a diagnosis consistent with previous MI.

Results: A total of 937 ECGs were interpreted, 538 men (57.4%) and 399 women (42.6%). Mean age at the time of ECG acquisition was 40.6 years (95% CI: 39.7-41.5, range: 15.9-94.6). We identified 32 patients with positive ECG signs of MIs. Only two of these patients had a diagnosis of MI in the National Patient Registry. An additional number of eight patients had a diagnosis of MI in the Danish National Patient Registry, but with no ECG signs of previous MI. This means that 30 out of 40 (75%) MIs were unrecognised. Only increasing age was associated with unrecognised MI in a stepwise multiple logistic regression model compared with patients with no history of MI, OR: 1.03 per year of age, 95% CI: 1.00-1.06, p=0.021.

Conclusion: Unrecognised MI is common among patients with schizophrenia and may contribute to the increased mortality found in this patient group.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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