{"title":"通过宏基因组学发现新的抗生素耐药基因。","authors":"Marcos López-Pérez, Salvador Mirete","doi":"10.2174/2352092208666141013231244","DOIUrl":null,"url":null,"abstract":"<p><p>Antibiotic resistance (AR) represents a challenge for the treatment of infectious diseases. Traditionally, antibiotic resistance determinants have been retrieved from culturable bacteria which represent a minor fraction of the total microbial diversity found in natural environments such as soils. In this review, we summarize recent advances in the study of antibiotic resistance using two main culture-independent approaches: sequence-based metagenomics and functional metagenomics. </p>","PeriodicalId":90715,"journal":{"name":"Recent advances in DNA & gene sequences","volume":"8 1","pages":"15-9"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Discovery of novel antibiotic resistance genes through metagenomics.\",\"authors\":\"Marcos López-Pérez, Salvador Mirete\",\"doi\":\"10.2174/2352092208666141013231244\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Antibiotic resistance (AR) represents a challenge for the treatment of infectious diseases. Traditionally, antibiotic resistance determinants have been retrieved from culturable bacteria which represent a minor fraction of the total microbial diversity found in natural environments such as soils. In this review, we summarize recent advances in the study of antibiotic resistance using two main culture-independent approaches: sequence-based metagenomics and functional metagenomics. </p>\",\"PeriodicalId\":90715,\"journal\":{\"name\":\"Recent advances in DNA & gene sequences\",\"volume\":\"8 1\",\"pages\":\"15-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Recent advances in DNA & gene sequences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/2352092208666141013231244\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent advances in DNA & gene sequences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2352092208666141013231244","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Discovery of novel antibiotic resistance genes through metagenomics.
Antibiotic resistance (AR) represents a challenge for the treatment of infectious diseases. Traditionally, antibiotic resistance determinants have been retrieved from culturable bacteria which represent a minor fraction of the total microbial diversity found in natural environments such as soils. In this review, we summarize recent advances in the study of antibiotic resistance using two main culture-independent approaches: sequence-based metagenomics and functional metagenomics.
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