关注药物与疾病机制和临床亚群,推进精神病学个体化治疗。

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Jose de Leon
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引用次数: 9

摘要

个性化医疗最终在精神病学期刊上出现,但精神科医生主要关注的是利用疾病机制进行个性化治疗的前景。精神疾病,如精神分裂症和抑郁症,在医学意义上不是疾病,而更像是综合症。作者认为,精神科医生不应该花费大量时间和精力关注可能是综合症的疾病机制,而是应该(1)通过药物机制(一种个性化医疗的药理学方法)更多地了解个性化处方;(2)重新考虑传统临床精神药理学家先前的尝试,即使用复杂的临床方法,试图将精神症状细分为治疗反应可能更均匀的组。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Focusing on drug versus disease mechanisms and on clinical subgrouping to advance personalised medicine in psychiatry.

Personalised medicine has finally been featured in psychiatric journals, but psychiatrists have mainly focused on the promise of using disease mechanisms to personalise treatment. Psychiatric disorders such as schizophrenia and depression are not diseases, in the medical sense, and are probably more like syndromes. Instead of spending much time and effort focusing on the mechanisms of diseases that may instead be syndromes, the author believes that psychiatrists should (1) learn more about personalising prescription via drug mechanisms, a pharmacological approach to personalised medicine; and (2) reconsider prior attempts by traditional clinical psychopharmacologists to use sophisticated clinical approaches that try to subdivide psychiatric syndromes into groups that may be more homogenous for treatment response.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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