保护重编程基因组的线粒体策略

IF 4 Q2 CELL & TISSUE ENGINEERING

Cell Regeneration Pub Date : 2014-01-01 DOI:10.1186/2045-9769-3-5

Alessandro Prigione , James Adjaye

引用次数: 1

摘要

体细胞重编程引起的基因组畸变是该技术未来在再生医学中应用的主要缺陷。Ji等人发表在《干细胞报告》上的一项新研究提出了一种通过补充抗氧化剂来平衡线粒体/氧化应激途径的对抗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A mitochondrial strategy for safeguarding the reprogrammed genome

查看原文本刊更多论文

A mitochondrial strategy for safeguarding the reprogrammed genome

Genomic aberrations induced by somatic cell reprogramming are a major drawback for future applications of this technology in regenerative medicine. A new study by Ji et al. published in Stem Cell Reports suggests a counteracting strategy based on balancing the mitochondrial/oxidative stress pathway through antioxidant supplementation.

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来源期刊

Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine