男性精神分裂症患者血浆中催产素和抗利尿激素水平降低。

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Acta Neuropsychiatrica Pub Date : 2014-12-01 Epub Date: 2014-10-07 DOI:10.1017/neu.2014.20
Andrea Jobst, Sandra Dehning, Simone Ruf, Tobias Notz, Anna Buchheim, Kristina Henning-Fast, Dominik Meißner, Sebastian Meyer, Brigitta Bondy, Norbert Müller, Peter Zill
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引用次数: 74

摘要

目的:社会功能障碍和自闭症症状是精神分裂症的特征。社会激素催产素(OT)和精氨酸-加压素(AVP)都调节社会互动,因此可能参与精神分裂症的发病机制。我们调查了精神分裂症患者与健康对照(HC)相比,是否表现出OT和AVP水平的改变,以及自闭症症状是否与OT水平相关。方法:纳入41例非急性精神分裂症患者和45例匹配的HC患者。采用阳性和阴性症状量表(PANSS)对精神分裂症进行评估。第2天采血,ELISA免疫法测定血浆OT和AVP水平。结果:精神分裂症患者血浆OT水平明显低于HC患者;AVP也有类似的趋势。血浆OT水平与严重生活事件、重要依附者较少、PANSS负量表得分较高相关;最主要的PANSS项目是“专注”、“情绪退缩”和“被动/冷漠社会退缩”。结论:这些发现支持社会激素OT和AVP与精神分裂症之间的关联。我们认为,精神分裂症患者血浆OT代谢可能发生改变,但导致血浆OT水平下降的其他可能原因包括OT合成、mRNA表达和翻译减少。尤其是精神分裂症的“自闭症”症状似乎与OT(一种“依恋”激素)代谢的改变密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxytocin and vasopressin levels are decreased in the plasma of male schizophrenia patients.
Objective Impaired social functioning and autistic symptoms are characteristics of schizophrenia. The social hormones oxytocin (OT) and arginine-vasopressin (AVP) both modulate social interaction and therefore may be involved in the pathogenesis of schizophrenia. We investigated whether men with schizophrenia show altered OT and AVP levels compared with healthy controls (HC) and whether autism symptoms are associated with OT levels. Methods Forty-one men with non-acute schizophrenia and 45 matched HC were enroled. Schizophrenia was assessed with the Positive and Negative Syndrome Scale (PANSS). Blood samples were collected on 2 days, and plasma OT and AVP levels were measured by ELISA immunoassay. Results The schizophrenia patients had significantly lower plasma OT levels than the HC; a similar trend was found for AVP. Plasma OT levels were associated with severe life events, fewer important attached persons, and a higher score on the PANSS negative scale; the most dominant PANSS items were ‘preoccupation’, ‘emotional withdrawal’, and ‘passive/apathetic social withdrawal’. Conclusion These findings support an association between the social hormones OT and AVP and schizophrenia. We suggest that OT metabolism may be altered in schizophrenia, but other possible causes for decreased plasma OT levels in schizophrenia patients include decreased OT synthesis, mRNA expression, and translation. Especially the ‘autistic’ symptoms of schizophrenia seem to be closely linked to an altered metabolism of OT, the ‘attachment’ hormone.
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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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