口腔鳞状细胞癌三级淋巴结构的特征及预后价值。

Q2 Medicine
BMC Clinical Pathology Pub Date : 2014-08-23 eCollection Date: 2014-01-01 DOI:10.1186/1472-6890-14-38
Anna M Wirsing, Oddveig G Rikardsen, Sonja E Steigen, Lars Uhlin-Hansen, Elin Hadler-Olsen
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引用次数: 83

摘要

背景:口腔鳞状细胞癌常被免疫细胞大量浸润。b细胞、滤泡树突状细胞、t细胞和高内皮小静脉组织形成的三级淋巴结构已在各种类型的癌症中被发现,它们的存在预示着有利的结果。本研究的目的是评估口腔鳞状细胞癌中三级淋巴结构的发生率,如果存在,分析它们是否与临床结果相关。方法:对80例口腔鳞状细胞癌的肿瘤标本进行b细胞、滤泡树突状细胞、t细胞、生发中心b细胞和高内皮小静脉的免疫组化染色。一些样本在多个水平上进行切片,以评估肿瘤内三级淋巴结构是否存在变化。结果:在21%的肿瘤中检测到肿瘤相关的三级淋巴结构,并与较低的疾病特异性死亡率相关。在组织块的不同层次上,三级淋巴结构的存在是不同的。结论:三级淋巴结构的形成是口腔鳞状细胞癌患者预后的积极因素。增加对口腔鳞状细胞癌三级淋巴结构形成的了解可能有助于开发和指导免疫调节癌症治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma.

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma.

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma.

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma.

Background: Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer, where their presence is found to predict favourable outcome. The purpose of the present study was to evaluate the incidence of tertiary lymphoid structures in oral squamous cell carcinomas, and if present, analyse whether they were associated with clinical outcome.

Methods: Tumour samples from 80 patients with oral squamous cell carcinoma were immunohistochemically stained for B-cells, follicular dendritic cells, T-cells, germinal centre B-cells and high-endothelial venules. Some samples were sectioned at multiple levels to assess whether the presence of tertiary lymphoid structures varied within the tumour.

Results: Tumour-associated tertiary lymphoid structures were detected in 21 % of the tumours and were associated with lower disease-specific death. The presence of tertiary lymphoid structures varied within different levels of a tissue block.

Conclusions: Tertiary lymphoid structure formation was found to be a positive prognostic factor for patients with oral squamous cell carcinoma. Increased knowledge about tertiary lymphoid structure formation in oral squamous cell carcinoma might help to develop and guide immune-modulatory cancer treatments.

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来源期刊
BMC Clinical Pathology
BMC Clinical Pathology Medicine-Pathology and Forensic Medicine
CiteScore
3.30
自引率
0.00%
发文量
0
期刊介绍: BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.
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