Walter J May, Ryan B Gruber, Joseph F Discala, Veljko Puskovic, Fraser Henderson, Lisa A Palmer, Stephen J Lewis
{"title":"吗啡对缺氧挑战的通气反应有潜在的有害影响。","authors":"Walter J May, Ryan B Gruber, Joseph F Discala, Veljko Puskovic, Fraser Henderson, Lisa A Palmer, Stephen J Lewis","doi":"10.4236/ojmip.2013.34022","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of this study was to determine whether morphine depresses the ventilatory responses elicited by a hypoxic challenge (10% O<sub>2</sub>, 90% N<sub>2</sub>) in conscious rats at a time when the effects of morphine on arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient and minute ventilation (V<sub>M</sub>) had completely subsided. In vehicle-treated rats, each episode of hypoxia stimulated ventilatory function and the responses generally subsided during each normoxic period. Morphine (5 mg/kg, i.v.) induced an array of depressant effects on ABG chemistry, A-a gradient and V<sub>M</sub> (via decreases in tidal volume). Despite resolution of these morphine-induced effects, the first episode of hypoxia elicited substantially smaller increases in V<sub>M</sub> than in vehicle-treated rats, due mainly to smaller increases in frequency of breathing. The pattern of ventilatory responses during subsequent episodes of hypoxia and normoxia changed substantially in morphine-treated rats. It is evident that morphine has latent deleterious effects on ventilatory responses elicited by hypoxic challenge.</p>","PeriodicalId":71307,"journal":{"name":"分子和综合生理学期刊(英文)","volume":"3 4","pages":"166-180"},"PeriodicalIF":0.0000,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103751/pdf/nihms570493.pdf","citationCount":"19","resultStr":"{\"title\":\"Morphine has latent deleterious effects on the ventilatory responses to a hypoxic challenge.\",\"authors\":\"Walter J May, Ryan B Gruber, Joseph F Discala, Veljko Puskovic, Fraser Henderson, Lisa A Palmer, Stephen J Lewis\",\"doi\":\"10.4236/ojmip.2013.34022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The aim of this study was to determine whether morphine depresses the ventilatory responses elicited by a hypoxic challenge (10% O<sub>2</sub>, 90% N<sub>2</sub>) in conscious rats at a time when the effects of morphine on arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient and minute ventilation (V<sub>M</sub>) had completely subsided. In vehicle-treated rats, each episode of hypoxia stimulated ventilatory function and the responses generally subsided during each normoxic period. Morphine (5 mg/kg, i.v.) induced an array of depressant effects on ABG chemistry, A-a gradient and V<sub>M</sub> (via decreases in tidal volume). Despite resolution of these morphine-induced effects, the first episode of hypoxia elicited substantially smaller increases in V<sub>M</sub> than in vehicle-treated rats, due mainly to smaller increases in frequency of breathing. The pattern of ventilatory responses during subsequent episodes of hypoxia and normoxia changed substantially in morphine-treated rats. It is evident that morphine has latent deleterious effects on ventilatory responses elicited by hypoxic challenge.</p>\",\"PeriodicalId\":71307,\"journal\":{\"name\":\"分子和综合生理学期刊(英文)\",\"volume\":\"3 4\",\"pages\":\"166-180\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103751/pdf/nihms570493.pdf\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"分子和综合生理学期刊(英文)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4236/ojmip.2013.34022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"分子和综合生理学期刊(英文)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4236/ojmip.2013.34022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Morphine has latent deleterious effects on the ventilatory responses to a hypoxic challenge.
The aim of this study was to determine whether morphine depresses the ventilatory responses elicited by a hypoxic challenge (10% O2, 90% N2) in conscious rats at a time when the effects of morphine on arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient and minute ventilation (VM) had completely subsided. In vehicle-treated rats, each episode of hypoxia stimulated ventilatory function and the responses generally subsided during each normoxic period. Morphine (5 mg/kg, i.v.) induced an array of depressant effects on ABG chemistry, A-a gradient and VM (via decreases in tidal volume). Despite resolution of these morphine-induced effects, the first episode of hypoxia elicited substantially smaller increases in VM than in vehicle-treated rats, due mainly to smaller increases in frequency of breathing. The pattern of ventilatory responses during subsequent episodes of hypoxia and normoxia changed substantially in morphine-treated rats. It is evident that morphine has latent deleterious effects on ventilatory responses elicited by hypoxic challenge.