绝经后妇女代谢综合征及其组成与骨骼状况的关系。

D Fodor, S Vesa, A Albu, S Simon, A Craciun, Laura Muntean
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引用次数: 9

摘要

未标记:代谢综合征(MS)和骨骼状态之间的关系仍然存在争议。我们的目的是研究绝经后妇女MS、骨密度(BMD)和骨代谢之间的关系。材料和方法:对218名白人绝经后妇女进行MS评估。采用双能x线骨密度仪(DXA)测量骨密度(腰椎和髋关节)。测定血清1型胶原羧基末端交联末端肽(CTX)、欠羧基化骨钙素(uOC)、骨碱性磷酸盐(BAP)和维生素D。结果:绝经后MS患者腰椎骨密度明显高于非MS患者(p < 0.05)。观察到两个部位的骨密度随MS组分的增加而逐渐增加。在未调整的分析中,骨密度与体重指数(BMI)、腰围(WC)和葡萄糖呈正相关的两个部位的骨密度对骨转换标志物和维生素D水平没有显著影响。在多元回归分析中,WC与两个部位的骨密度独立相关,而高血压仅与腰椎骨密度相关。结论:绝经后妇女,MS与腰椎骨密度增高有关,这种关系主要是由MS组BMI和WC增高来解释的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The relationship between the metabolic syndrome and its components and bone status in postmenopausal women.

Unlabelled: The association between metabolic syndrome (MS) and bone status remains controversial. We aimed to study the relationships between MS, bone mineral density (BMD), and bone metabolism in postmenopausal women.

Material and methods: MS was assessed in 218 white postmenopausal women. BMD (lumbar spine and hip) was measured by dual energy X-ray absorptiometry (DXA). Serum carboxyterminal cross-linked telopeptide of type 1 collagen (CTX), undercarboxylated osteocalcin (uOC), bone alkaline phosphate (BAP) and vitamin D were assayed.

Results: Postmenopausal women with MS had a significantly higher lumber spine BMD than women without MS (p < 0.05). A progressive increase of the BMD at both sites with the number of MS components was observed. Bone turnover markers and vitamin D levels were not significantly influenced by the presence of MS. BMD at both sites positively correlated with body mass index (BMI), waist circumference (WC) and glucose in unadjusted analysis. In multiple regression analysis, WC was independently associated with BMD at both sites, while hypertension was associated only with lumbar spine BMD.

Conclusions: In postmenopausal women, MS is associated with increased lumbar spine BMD and this relation is explained mainly by the higher BMI and WC in the MS group.

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来源期刊
Acta physiologica Hungarica
Acta physiologica Hungarica 医学-生理学
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