先前未经治疗的口腔鳞状细胞癌选择性颈部清扫后的局部失败。

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2014-01-01 Epub Date: 2014-03-11 DOI:10.1155/2014/205715
Hassan Iqbal, Abu Bakar Hafeez Bhatti, Raza Hussain, Arif Jamshed
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引用次数: 15

摘要

目的:探讨未经治疗的口腔鳞状细胞癌淋巴结阴性和阳性患者选择性颈部清扫术后局部失败的经验。患者和方法:回顾性分析2003 - 2010年在Shaukat Khanum肿瘤医院接受SND治疗的219例患者的资料。评估患者特征、治疗方式和局部失败。计算预期5年区域控制率并确定预后因素。结果:中位随访时间为29(9-109)个月。常见部位为舌前159例,颊黏膜22例。病理分期为N0型114例,N1型32例,N2b型67例,N2c型5例。14例(6%)临床淋巴结阴性患者失败,8例(4%)临床淋巴结阳性患者失败。在22例局部失败中,16例(73%)患者的原发肿瘤来自舌头。N0和N+疾病的5年预期区域控制率分别为95%和81% (P < 0.0001)。只有13%的cN0颈部高分化T1肿瘤病理淋巴结阳性。结论:选择性颈部清扫术对口腔鳞状细胞癌的局部治疗效果可接受。观望政策可能对选定的亚组患者有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regional failures after selective neck dissection in previously untreated squamous cell carcinoma of oral cavity.

Aim: To share experience with regional failures after selective neck dissection in both node negative and positive previously untreated patients diagnosed with squamous cell carcinoma of the oral cavity.

Patients and methods: Data of 219 patients who underwent SND at Shaukat Khanum Cancer Hospital from 2003 to 2010 were retrospectively reviewed. Patient characteristics, treatment modalities, and regional failures were assessed. Expected 5-year regional control was calculated and prognostic factors were determined.

Results: Median follow-up was 29 (9-109) months. Common sites were anterior tongue in 159 and buccal mucosa in 22 patients. Pathological nodal stage was N0 in 114, N1 in 32, N2b in 67, and N2c in 5 patients. Fourteen (6%) patients failed in clinically node negative neck while 8 (4%) failed in clinically node positive patients. Out of 22 total regional failures, primary tumor origin was from tongue in 16 (73%) patients. Expected 5-year regional control was 95% and 81% for N0 and N+ disease, respectively (P < 0.0001). Only 13% patients with well differentiated, T1 tumors in cN0 neck were pathologically node positive.

Conclusions: Selective neck dissection yields acceptable results for regional management of oral squamous cell carcinoma. Wait and see policy may be effective in a selected subgroup of patients.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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