Bruno Fonseca-Santos PhD , Camila André Cazarin MSc , Patrícia Bento da Silva PhD , Kaio Pini dos Santos PhD , Márcia Cristina Oliveira da Rocha PhD , Sônia Nair Báo PhD , Márcia Maria De-Souza PhD , Marlus Chorilli PhD
{"title":"鼻内原位胶凝液晶传递白藜芦醇改善阿尔茨海默病的记忆和神经炎症","authors":"Bruno Fonseca-Santos PhD , Camila André Cazarin MSc , Patrícia Bento da Silva PhD , Kaio Pini dos Santos PhD , Márcia Cristina Oliveira da Rocha PhD , Sônia Nair Báo PhD , Márcia Maria De-Souza PhD , Marlus Chorilli PhD","doi":"10.1016/j.nano.2023.102689","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects around 6.5 million in the United States. </span>Resveratrol<span><span><span> is a chemical obtained from natural products and it exhibits biological activity based on inhibiting the formation, </span>depolymerization<span><span> of the amyloid, and decreasing neuroinflammation. Due to the insolubility of this compound; its incorporation in surfactant-based systems was proposed to design an intranasal formulation. A range of systems has been produced by mixing </span>oleic acid, CETETH-20 and water. </span></span>Polarised light microscopy (PLM), small angle x-ray scattering (SAXS) and </span></span>transmission electron microscopy<span> (TEM) confirm the initial liquid formulation (F) presented as microemulsion<span> (ME). After dilution, the gelled systems were characterized as hexagonal mesophase and they showed feasibility proprieties. Pharmacological assays performed after intranasal administration showed the ability to improve learning and memory in animals, as well as remission of neuroinflammation </span></span></span><em>via</em><span> inhibition of interleukin.</span></p></div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"51 ","pages":"Article 102689"},"PeriodicalIF":4.7000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Intranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease\",\"authors\":\"Bruno Fonseca-Santos PhD , Camila André Cazarin MSc , Patrícia Bento da Silva PhD , Kaio Pini dos Santos PhD , Márcia Cristina Oliveira da Rocha PhD , Sônia Nair Báo PhD , Márcia Maria De-Souza PhD , Marlus Chorilli PhD\",\"doi\":\"10.1016/j.nano.2023.102689\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span>Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects around 6.5 million in the United States. </span>Resveratrol<span><span><span> is a chemical obtained from natural products and it exhibits biological activity based on inhibiting the formation, </span>depolymerization<span><span> of the amyloid, and decreasing neuroinflammation. Due to the insolubility of this compound; its incorporation in surfactant-based systems was proposed to design an intranasal formulation. A range of systems has been produced by mixing </span>oleic acid, CETETH-20 and water. </span></span>Polarised light microscopy (PLM), small angle x-ray scattering (SAXS) and </span></span>transmission electron microscopy<span> (TEM) confirm the initial liquid formulation (F) presented as microemulsion<span> (ME). After dilution, the gelled systems were characterized as hexagonal mesophase and they showed feasibility proprieties. Pharmacological assays performed after intranasal administration showed the ability to improve learning and memory in animals, as well as remission of neuroinflammation </span></span></span><em>via</em><span> inhibition of interleukin.</span></p></div>\",\"PeriodicalId\":396,\"journal\":{\"name\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"volume\":\"51 \",\"pages\":\"Article 102689\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomedicine: Nanotechnology, Biology and Medicine\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1549963423000400\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine: Nanotechnology, Biology and Medicine","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1549963423000400","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Intranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease
Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects around 6.5 million in the United States. Resveratrol is a chemical obtained from natural products and it exhibits biological activity based on inhibiting the formation, depolymerization of the amyloid, and decreasing neuroinflammation. Due to the insolubility of this compound; its incorporation in surfactant-based systems was proposed to design an intranasal formulation. A range of systems has been produced by mixing oleic acid, CETETH-20 and water. Polarised light microscopy (PLM), small angle x-ray scattering (SAXS) and transmission electron microscopy (TEM) confirm the initial liquid formulation (F) presented as microemulsion (ME). After dilution, the gelled systems were characterized as hexagonal mesophase and they showed feasibility proprieties. Pharmacological assays performed after intranasal administration showed the ability to improve learning and memory in animals, as well as remission of neuroinflammation via inhibition of interleukin.
期刊介绍：
Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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