Ganna Chornokur, Ernest K Amankwah, Stacy N Davis, Catherine M Phelan, Jong Y Park, Julio Pow-Sang, Nagi B Kumar
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引用次数: 18
摘要
背景。前列腺癌(PCa)的种族差异是多因素的，涉及生物学、社会文化和生活方式的决定因素。我们研究了黑人(AAM)和白人(EAM)男性中选定的潜在功能多态性(snp)与前列腺癌(PCa)风险之间的关系。我们进一步探讨了这些关联是否因体重指数(BMI)和身高而异。方法。利用TaqMan等位基因分化分析，对259份AAM和269份EAM的年龄匹配DNA样本进行了7个基因的10个候选snp的基因分型。拟合了显性、隐性和加性年龄调整无条件logistic回归模型。结果。AAM、HNF1B、rs7501939 (OR = 2.42, P = 0.0046)、rs4430796 (OR = 0.57, P = 0.0383) 3个snp与PCa风险有统计学意义;在EAM中，CTBP2 rs4962416 (OR = 1.52, P = 0.0384)。此外，AAM的高BMI (OR = 1.06, P = 0.022)与EAM的高身高(OR = 0.92, P = 0.0434)呈显著相关。有趣的是，HNF1B rs7501939仅在肥胖AAM中与PCa相关(OR = 2.14, P = 0.0103)。结论。我们的研究结果表明，HNF1B的变异可能影响肥胖AAM中PCa的风险。
Variation in HNF1B and Obesity May Influence Prostate Cancer Risk in African American Men: A Pilot Study.
Background. Prostate cancer (PCa) racial disparity is multifactorial, involving biological, sociocultural, and lifestyle determinants. We investigated the association between selected potentially functional polymorphisms (SNPs) and prostate cancer (PCa) risk in Black (AAM) and White (EAM) men. We further explored if these associations varied by the body mass index (BMI) and height. Methods. Age-matched DNA samples from 259 AAM and 269 EAM were genotyped for 10 candidate SNPs in 7 genes using the TaqMan allelic differentiation analysis. The dominant, recessive, and additive age-adjusted unconditional logistic regression models were fitted. Results. Three SNPs showed statistically significant associations with PCa risk: in AAM, HNF1B rs7501939 (OR = 2.42, P = 0.0046) and rs4430796 (OR = 0.57, P = 0.0383); in EAM, CTBP2 rs4962416 (OR = 1.52, P = 0.0384). In addition, high BMI in AAM (OR = 1.06, P = 0.022) and height in EAM (OR = 0.92, P = 0.0434) showed significant associations. Interestingly, HNF1B rs7501939 was associated with PCa exclusively in obese AAM (OR = 2.14, P = 0.0103). Conclusion. Our results suggest that variation in the HNF1B may influence PCa risk in obese AAM.
期刊介绍：
Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.
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