白色念珠菌:研究真菌病原体的模式生物。

ISRN Microbiology Pub Date : 2012-09-29 Print Date: 2012-01-01 DOI:10.5402/2012/538694
M Anaul Kabir, Mohammad Asif Hussain, Zulfiqar Ahmad
{"title":"白色念珠菌:研究真菌病原体的模式生物。","authors":"M Anaul Kabir,&nbsp;Mohammad Asif Hussain,&nbsp;Zulfiqar Ahmad","doi":"10.5402/2012/538694","DOIUrl":null,"url":null,"abstract":"<p><p>Candida albicans is an opportunistic human fungal pathogen that causes candidiasis. As healthcare has been improved worldwide, the number of immunocompromised patients has been increased to a greater extent and they are highly susceptible to various pathogenic microbes and C. albicans has been prominent among the fungal pathogens. The complete genome sequence of this pathogen is now available and has been extremely useful for the identification of repertoire of genes present in this pathogen. The major challenge is now to assign the functions to these genes of which 13% are specific to C. albicans. Due to its close relationship with yeast Saccharomyces cerevisiae, an edge over other fungal pathogens because most of the technologies can be directly transferred to C. albicans from S. cerevisiae and it is amenable to mutation, gene disruption, and transformation. The last two decades have witnessed enormous amount of research activities on this pathogen that leads to the understanding of host-parasite interaction, infections, and disease propagation. Clearly, C. albicans has emerged as a model organism for studying fungal pathogens along with other two fungi Aspergillus fumigatus and Cryptococcus neoformans. Understanding its complete life style of C. albicans will undoubtedly be useful for developing potential antifungal drugs and tackling Candida infections. This will also shed light on the functioning of other fungal pathogens.</p>","PeriodicalId":14849,"journal":{"name":"ISRN Microbiology","volume":"2012 ","pages":"538694"},"PeriodicalIF":0.0000,"publicationDate":"2012-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/538694","citationCount":"136","resultStr":"{\"title\":\"Candida albicans: A Model Organism for Studying Fungal Pathogens.\",\"authors\":\"M Anaul Kabir,&nbsp;Mohammad Asif Hussain,&nbsp;Zulfiqar Ahmad\",\"doi\":\"10.5402/2012/538694\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Candida albicans is an opportunistic human fungal pathogen that causes candidiasis. As healthcare has been improved worldwide, the number of immunocompromised patients has been increased to a greater extent and they are highly susceptible to various pathogenic microbes and C. albicans has been prominent among the fungal pathogens. The complete genome sequence of this pathogen is now available and has been extremely useful for the identification of repertoire of genes present in this pathogen. The major challenge is now to assign the functions to these genes of which 13% are specific to C. albicans. Due to its close relationship with yeast Saccharomyces cerevisiae, an edge over other fungal pathogens because most of the technologies can be directly transferred to C. albicans from S. cerevisiae and it is amenable to mutation, gene disruption, and transformation. The last two decades have witnessed enormous amount of research activities on this pathogen that leads to the understanding of host-parasite interaction, infections, and disease propagation. Clearly, C. albicans has emerged as a model organism for studying fungal pathogens along with other two fungi Aspergillus fumigatus and Cryptococcus neoformans. Understanding its complete life style of C. albicans will undoubtedly be useful for developing potential antifungal drugs and tackling Candida infections. This will also shed light on the functioning of other fungal pathogens.</p>\",\"PeriodicalId\":14849,\"journal\":{\"name\":\"ISRN Microbiology\",\"volume\":\"2012 \",\"pages\":\"538694\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.5402/2012/538694\",\"citationCount\":\"136\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ISRN Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5402/2012/538694\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2012/1/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ISRN Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5402/2012/538694","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/1/1 0:00:00","PubModel":"Print","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 136

摘要

白色念珠菌是一种导致念珠菌病的机会性人类真菌病原体。随着世界范围内卫生保健水平的提高,免疫功能低下患者的数量越来越多,他们对各种病原微生物非常敏感,白色念珠菌在真菌病原体中占有突出地位。这种病原体的完整基因组序列现在是可用的,并且对鉴定这种病原体中存在的基因库非常有用。目前的主要挑战是为这些基因分配功能,其中13%是白色念珠菌特有的。由于其与酿酒酵母的密切关系,与其他真菌病原体相比具有优势,因为大多数技术可以直接从酿酒酵母转移到白色念珠菌,并且它易于突变,基因破坏和转化。在过去的二十年里,人们对这种病原体进行了大量的研究,从而了解了宿主-寄生虫的相互作用、感染和疾病传播。显然,白色念珠菌已与其他两种真菌烟曲霉和新型隐球菌一起成为研究真菌病原体的模式生物。了解白色念珠菌的完整生活方式无疑将有助于开发潜在的抗真菌药物和治疗念珠菌感染。这也将阐明其他真菌病原体的功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Candida albicans: A Model Organism for Studying Fungal Pathogens.

Candida albicans: A Model Organism for Studying Fungal Pathogens.

Candida albicans is an opportunistic human fungal pathogen that causes candidiasis. As healthcare has been improved worldwide, the number of immunocompromised patients has been increased to a greater extent and they are highly susceptible to various pathogenic microbes and C. albicans has been prominent among the fungal pathogens. The complete genome sequence of this pathogen is now available and has been extremely useful for the identification of repertoire of genes present in this pathogen. The major challenge is now to assign the functions to these genes of which 13% are specific to C. albicans. Due to its close relationship with yeast Saccharomyces cerevisiae, an edge over other fungal pathogens because most of the technologies can be directly transferred to C. albicans from S. cerevisiae and it is amenable to mutation, gene disruption, and transformation. The last two decades have witnessed enormous amount of research activities on this pathogen that leads to the understanding of host-parasite interaction, infections, and disease propagation. Clearly, C. albicans has emerged as a model organism for studying fungal pathogens along with other two fungi Aspergillus fumigatus and Cryptococcus neoformans. Understanding its complete life style of C. albicans will undoubtedly be useful for developing potential antifungal drugs and tackling Candida infections. This will also shed light on the functioning of other fungal pathogens.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信