清醒大鼠下丘脑后部NO在杏仁核产生的压力反应中的作用

H. Özyurt Bayraktar, H. Yananlı, B. Terzioğlu, Ş. Oktay, M. Kaleli, M. Z. Gören
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引用次数: 1

摘要

氮能系统调节杏仁核中央核(CeA)和下丘脑后核(PH)的心血管功能,参与心血管系统的中枢调节。本研究的目的是探讨一氧化氮(NO)在PH中通过CeA电刺激(ES)引起心血管反应的作用。在大鼠CeA内植入刺激电极和实质插管系统,在ph内植入实质插管或微透析探针。第二天,在股动脉内插管进行血流动力学测量。电刺激CeA产生心血管反应。一氧化氮合成酶抑制剂ng -硝基- l -精氨酸甲酯;脑脊液分别注射于脑脊液中(400 nmol/100 nl)或脑脊液中。从PH处收集透析液,测定l -瓜氨酸和l -谷氨酸水平。L-NAME注射到CeA而不注射到PH显著抑制CeA ES产生的平均动脉压升高;然而,在PH或CeA注射L-NAME对心率没有影响。经CeA的ES处理后,PH中l -瓜氨酸和l -谷氨酸水平升高。一氧化氮参与到PH和CeA之间,在心血管系统的中枢调节中起着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of NO in the posterior hypothalamus in amygdala-generated pressor responses in conscious rats

  1. The nitrergic system modulates cardiovascular functions of the central nucleus of amygdala (CeA) and the posterior hypothalamus (PH) which are involved in the central regulation of the cardiovascular system. The aim of this study was to investigate the contribution of nitric oxide (NO) in the PH in eliciting cardiovascular responses produced through electrical stimulation (ES) of the CeA. Rats were implanted with a stimulation electrode and a parenchymal cannula system into the CeA and a parenchymal cannula or a microdialysis probe into the PH. The next day, the femoral artery was cannulated for haemodynamic measurement. The CeA was electrically stimulated to produce cardiovascular response. The nitric oxide synthetase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 400 nmol/100 nl) or artificial cerebrospinal fluid were injected into the PH or the CeA before the ES of the CeA. The dialysates were collected from the PH to determine the L-citrulline and the L-glutamic acid levels.
  2. L-NAME injection into the CeA but not to the PH suppressed the increases in the mean arterial pressure produced by the ES of the CeA significantly; however, heart rate was not affected by L-NAME injection into either the PH or the CeA. L-citrulline and L-glutamic acid levels in the PH were shown to be increased by the ES of the CeA.
  3. NO is involved between the PH and the CeA which has a considerable role in the central regulation of the cardiovascular system.
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